Metagenomics: application of genomics to uncultured microorganisms

J Handelsman - Microbiology and molecular biology reviews, 2004 - Am Soc Microbiol
Metagenomics (also referred to as environmental and community genomics) is the genomic
analysis of microorganisms by direct extraction and cloning of DNA from an assemblage of …

Review and re-analysis of domain-specific 16S primers

GC Baker, JJ Smith, DA Cowan - Journal of microbiological methods, 2003 - Elsevier
The Polymerase Chain Reaction (PCR) has facilitated the detection of unculturable
microorganisms in virtually any environmental source and has thus been used extensively in …

Sponge-associated microorganisms: evolution, ecology, and biotechnological potential

MW Taylor, R Radax, D Steger… - … and molecular biology …, 2007 - Am Soc Microbiol
Marine sponges often contain diverse and abundant microbial communities, including
bacteria, archaea, microalgae, and fungi. In some cases, these microbial associates …

The Sorcerer II Global Ocean Sampling Expedition: Northwest Atlantic through Eastern Tropical Pacific

DB Rusch, AL Halpern, G Sutton, KB Heidelberg… - PLoS …, 2007 - journals.plos.org
The world's oceans contain a complex mixture of micro-organisms that are for the most part,
uncharacterized both genetically and biochemically. We report here a metagenomic study of …

Metagenomics: genomic analysis of microbial communities

CS Riesenfeld, PD Schloss, J Handelsman - Annu. Rev. Genet., 2004 - annualreviews.org
▪ Abstract Uncultured microorganisms comprise the majority of the planet's biological
diversity. Microorganisms represent two of the three domains of life and contain vast …

Exploring prokaryotic diversity in the genomic era

P Hugenholtz - Genome biology, 2002 - Springer
Our understanding of prokaryote biology from study of pure cultures and genome
sequencing has been limited by a pronounced sampling bias towards four bacterial phyla …

The bacterial species definition in the genomic era

KT Konstantinidis, A Ramette… - … Transactions of the …, 2006 - royalsocietypublishing.org
The bacterial species definition, despite its eminent practical significance for identification,
diagnosis, quarantine and diversity surveys, remains a very difficult issue to advance …

Marine sponges as microbial fermenters

U Hentschel, KM Usher… - FEMS microbiology …, 2006 - academic.oup.com
The discovery of phylogenetically complex, yet highly sponge-specific microbial
communities in marine sponges, including novel lineages and even candidate phyla, came …

Cleaning up with genomics: applying molecular biology to bioremediation

DR Lovley - Nature Reviews Microbiology, 2003 - nature.com
Bioremediation has the potential to restore contaminated environments inexpensively yet
effectively, but a lack of information about the factors controlling the growth and metabolism …

[图书][B] Anticancer agents from natural products

GM Cragg, DGI Kingston, DJ Newman - 2005 - taylorfrancis.com
Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …