[HTML][HTML] New approach methodologies in human regulatory toxicology–Not if, but how and when!
S Schmeisser, A Miccoli, M von Bergen… - Environment …, 2023 - Elsevier
The predominantly animal-centric approach of chemical safety assessment has increasingly
come under pressure. Society is questioning overall performance, sustainability, continued …
come under pressure. Society is questioning overall performance, sustainability, continued …
[HTML][HTML] Complex chemical mixtures: Approaches for assessing adverse human health effects
E Mustafa, MJ Valente, AM Vinggaard - Current Opinion in Toxicology, 2023 - Elsevier
In this opinion, we provide a brief overview of three main approaches for assessing effects of
chemical mixtures on human health, such as experimental or theoretical component-based …
chemical mixtures on human health, such as experimental or theoretical component-based …
[HTML][HTML] Basic concepts of mixture toxicity and relevance for risk evaluation and regulation
D Bloch, P Diel, B Epe, M Hellwig, A Lampen… - Archives of …, 2023 - Springer
Exposure to multiple substances is a challenge for risk evaluation. Currently, there is an
ongoing debate if generic “mixture assessment/allocation factors”(MAF) should be …
ongoing debate if generic “mixture assessment/allocation factors”(MAF) should be …
[HTML][HTML] Maternal exposure to dibutyl phthalate (DBP) impairs angiogenesis and AR signalling pathway through suppression of TGFB1I1 in hypospadias offspring
L Wu, F Shi, Y Zhang, X Xu, Z Xie, S Hua, S Xia… - Ecotoxicology and …, 2024 - Elsevier
Early exposure to dibutyl phthalate (DBP) can cause hypospadias in newborn foetuses.
However, the underlying molecular mechanism is not well defined. Aberrant angiogenesis is …
However, the underlying molecular mechanism is not well defined. Aberrant angiogenesis is …