Ionizing radiation-induced epigenetic modifications and their relevance to radiation protection

M Belli, MA Tabocchini - International journal of molecular sciences, 2020 - mdpi.com
The present system of radiation protection assumes that exposure at low doses and/or low
dose-rates leads to health risks linearly related to the dose. They are evaluated by a …

Effects of ionizing radiation on DNA methylation: from experimental biology to clinical applications

IR Miousse, KR Kutanzi, I Koturbash - International journal of …, 2017 - Taylor & Francis
Purpose: Ionizing radiation (IR) is a ubiquitous environmental stressor with genotoxic and
epigenotoxic capabilities. Terrestrial IR, predominantly a low-linear energy transfer (LET) …

Ionizing radiation and human health: Reviewing models of exposure and mechanisms of cellular damage. An epigenetic perspective

E Burgio, P Piscitelli, L Migliore - International journal of environmental …, 2018 - mdpi.com
We reviewed available evidence in medical literature concerning experimental models of
exposure to ionizing radiations (IR) and their mechanisms of producing damages on living …

Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and …

JS Helm, RA Rudel - Archives of toxicology, 2020 - Springer
Abstract Knowledge about established breast carcinogens can support improved and
modernized toxicological testing methods by identifying key mechanistic events. Ionizing …

Ionizing radiation induces transgenerational effects of DNA methylation in zebrafish

JH Kamstra, S Hurem, LM Martin, LC Lindeman… - Scientific reports, 2018 - nature.com
Ionizing radiation is known to cause DNA damage, yet the mechanisms underlying potential
transgenerational effects of exposure have been scarcely studied. Previously, we observed …

Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier …

IR Miousse, R Pathak, S Garg, CM Skinner, S Melnyk… - Genes & nutrition, 2017 - Springer
Background Methionine, a central molecule in one-carbon metabolism, is an essential
amino acid required for normal growth and development. Despite its importance to …

Climate change and new challenges for rural communities: Particulate matter matters

IR Miousse, RB Hale, S Alsbrook, G Boysen… - Sustainability, 2023 - mdpi.com
Climate change presents multiple challenges to rural communities. Here, we investigated
the toxicological potential of the six types of particulate matter most common to rural …

Galactic cosmic radiation induces persistent epigenome alterations relevant to human lung cancer

EM Kennedy, DR Powell, Z Li, JSK Bell, BG Barwick… - Scientific reports, 2018 - nature.com
Human deep space and planetary travel is limited by uncertainties regarding the health risks
associated with exposure to galactic cosmic radiation (GCR), and in particular the high …

Epigenetic regulation in radiation-induced pulmonary fibrosis

J Li, R Wang, W Shi, X Chen, J Yi… - International Journal of …, 2023 - Taylor & Francis
Purpose Radiation-induced pulmonary fibrosis (RIPF) is a common and serious adverse
effect of radiotherapy for thoracic tumors, which occurs in the irreversible stage of radiation …

Inverse changes in L1 retrotransposons between blood and brain in major depressive disorder

S Liu, T Du, Z Liu, Y Shen, J Xiu, Q Xu - Scientific reports, 2016 - nature.com
Long interspersed nuclear element-1 (LINE-1 or L1) is a type of retrotransposons comprising
17% of the human and mouse genome, and has been found to be associated with several …