Ionizing radiation-induced epigenetic modifications and their relevance to radiation protection
M Belli, MA Tabocchini - International journal of molecular sciences, 2020 - mdpi.com
The present system of radiation protection assumes that exposure at low doses and/or low
dose-rates leads to health risks linearly related to the dose. They are evaluated by a …
dose-rates leads to health risks linearly related to the dose. They are evaluated by a …
Effects of ionizing radiation on DNA methylation: from experimental biology to clinical applications
IR Miousse, KR Kutanzi, I Koturbash - International journal of …, 2017 - Taylor & Francis
Purpose: Ionizing radiation (IR) is a ubiquitous environmental stressor with genotoxic and
epigenotoxic capabilities. Terrestrial IR, predominantly a low-linear energy transfer (LET) …
epigenotoxic capabilities. Terrestrial IR, predominantly a low-linear energy transfer (LET) …
Ionizing radiation and human health: Reviewing models of exposure and mechanisms of cellular damage. An epigenetic perspective
E Burgio, P Piscitelli, L Migliore - International journal of environmental …, 2018 - mdpi.com
We reviewed available evidence in medical literature concerning experimental models of
exposure to ionizing radiations (IR) and their mechanisms of producing damages on living …
exposure to ionizing radiations (IR) and their mechanisms of producing damages on living …
Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and …
JS Helm, RA Rudel - Archives of toxicology, 2020 - Springer
Abstract Knowledge about established breast carcinogens can support improved and
modernized toxicological testing methods by identifying key mechanistic events. Ionizing …
modernized toxicological testing methods by identifying key mechanistic events. Ionizing …
Ionizing radiation induces transgenerational effects of DNA methylation in zebrafish
Ionizing radiation is known to cause DNA damage, yet the mechanisms underlying potential
transgenerational effects of exposure have been scarcely studied. Previously, we observed …
transgenerational effects of exposure have been scarcely studied. Previously, we observed …
Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier …
IR Miousse, R Pathak, S Garg, CM Skinner, S Melnyk… - Genes & nutrition, 2017 - Springer
Background Methionine, a central molecule in one-carbon metabolism, is an essential
amino acid required for normal growth and development. Despite its importance to …
amino acid required for normal growth and development. Despite its importance to …
Climate change and new challenges for rural communities: Particulate matter matters
IR Miousse, RB Hale, S Alsbrook, G Boysen… - Sustainability, 2023 - mdpi.com
Climate change presents multiple challenges to rural communities. Here, we investigated
the toxicological potential of the six types of particulate matter most common to rural …
the toxicological potential of the six types of particulate matter most common to rural …
Galactic cosmic radiation induces persistent epigenome alterations relevant to human lung cancer
Human deep space and planetary travel is limited by uncertainties regarding the health risks
associated with exposure to galactic cosmic radiation (GCR), and in particular the high …
associated with exposure to galactic cosmic radiation (GCR), and in particular the high …
Epigenetic regulation in radiation-induced pulmonary fibrosis
J Li, R Wang, W Shi, X Chen, J Yi… - International Journal of …, 2023 - Taylor & Francis
Purpose Radiation-induced pulmonary fibrosis (RIPF) is a common and serious adverse
effect of radiotherapy for thoracic tumors, which occurs in the irreversible stage of radiation …
effect of radiotherapy for thoracic tumors, which occurs in the irreversible stage of radiation …
Inverse changes in L1 retrotransposons between blood and brain in major depressive disorder
S Liu, T Du, Z Liu, Y Shen, J Xiu, Q Xu - Scientific reports, 2016 - nature.com
Long interspersed nuclear element-1 (LINE-1 or L1) is a type of retrotransposons comprising
17% of the human and mouse genome, and has been found to be associated with several …
17% of the human and mouse genome, and has been found to be associated with several …