The transient receptor potential melastatin subtype 8 (TRPM8) is a nonselective, multimodal
ion channel, activated by low temperatures (< 28° C), pressure, and cooling compounds …

In mammals, the transient receptor potential (TRP) channels family consists of six different
families, namely TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPML …

A method for the C (sp3)–H alkenylation of N-aryl-tetrahydroisoquinoline (THIQ) has been
developed by the combination of electrooxidation and a copper catalyst. The corresponding …

Transient receptor potential melastatin-8 (TRPM8) represents an emerging target in prostate
cancer, although its mechanism of action remains unclear. Here, we have characterized and …

C (sp3)–H alkenylation of tetrahydroisoquinoline by merging Shono oxidation and the Morita–
Baylis–Hillman reaction is developed, employing 4-dimethylaminopyridine as an …

Transient-receptor-potential melastatin 8 (TRPM8), the predominant mammalian cold-
temperature thermosensor, is a nonselective cation channel expressed in a subpopulation …

The transient melastatin receptor potential (TRPM) ion channel subfamily functions as
cellular sensors and transducers of critical biological signal pathways by regulating ion …

TRPM8 has been implicated in nociception and pain and is currently regarded as an
attractive target for the pharmacological treatment of neuropathic pain syndromes. A series …

Convenient synthesis and useful application of a series of Josiphos-type binaphane ligands
were described. The iridium complexes of these chiral diphosphines displayed excellent …

Tetrahydroquinoline and isoquinoline scaffolds are important class of heterocyclic
compounds, which is implied for the development of new drugs and diagnostic for …