[HTML][HTML] Cell wall polysaccharides of Streptococci: a genetic and structural perspective

Z Kampff, D van Sinderen, J Mahony - Biotechnology Advances, 2023 - Elsevier
The Streptococcus genus comprises both commensal and pathogenic species. Additionally,
Streptococcus thermophilus is exploited in fermented foods and in probiotic preparations …

[HTML][HTML] Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID

JP Haran, E Bradley, AL Zeamer, L Cincotta… - Jci Insight, 2021 - ncbi.nlm.nih.gov
In the COVID-19 pandemic, caused by SARS-CoV-2, many individuals experience
prolonged symptoms, termed long-lasting COVID-19 symptoms (long COVID). Long COVID …

[HTML][HTML] Anti-tuberculosis drug development via targeting the cell envelope of Mycobacterium tuberculosis

X Xu, B Dong, L Peng, C Gao, Z He, C Wang… - Frontiers in …, 2022 - frontiersin.org
Mycobacterium tuberculosis possesses a dynamic cell envelope, which consists of a
peptidoglycan layer, a mycolic acid layer, and an arabinogalactan polysaccharide. This …

[HTML][HTML] Genomic diversity across the Rickettsia and 'Candidatus Megaira' genera and proposal of genus status for the Torix group

HR Davison, J Pilgrim, N Wybouw, J Parker… - Nature …, 2022 - nature.com
Members of the bacterial genus Rickettsia were originally identified as causative agents of
vector-borne diseases in mammals. However, many Rickettsia species are arthropod …

Human oral lectin ZG16B acts as a cell wall polysaccharide probe to decode host–microbe interactions with oral commensals

S Ghosh, CP Ahearn, CR Isabella… - Proceedings of the …, 2023 - National Acad Sciences
The oral microbiome is critical to human health and disease, yet the role that host salivary
proteins play in maintaining oral health is unclear. A highly expressed gene in human …

[HTML][HTML] Repurposing the Streptococcus mutans CRISPR-Cas9 System to Understand Essential Gene Function

RC Shields, AR Walker, N Maricic… - PLoS …, 2020 - journals.plos.org
A recent genome-wide screen identified~ 300 essential or growth-supporting genes in the
dental caries pathogen Streptococcus mutans. To be able to study these genes, we built a …

[HTML][HTML] Opportunities and challenges of bacterial glycosylation for the development of novel antibacterial strategies

L Yakovlieva, JA Fülleborn, MTC Walvoort - Frontiers in Microbiology, 2021 - frontiersin.org
Glycosylation is a ubiquitous process that is universally conserved in nature. The various
products of glycosylation, such as polysaccharides, glycoproteins, and glycolipids, perform a …

[HTML][HTML] PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides

JS Rush, P Parajuli, A Ruda, J Li, AA Pohane… - Nature …, 2022 - nature.com
The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of
peptidoglycan decorated with the Lancefield group A carbohydrate (GAC). GAC is a …

Gene expression and metabolic activity of Streptococcus mutans during exposure to dietary carbohydrates glucose, sucrose, lactose, and xylitol

V Jurakova, V Farková, J Kucera… - Molecular Oral …, 2023 - Wiley Online Library
Recent RNA sequencing studies have given us a deeper insight into the cariogenic impact
of carbohydrate sources in the bacterium Streptococcus mutans, the principal microbial …

NDP-rhamnose biosynthesis and rhamnosyltransferases: building diverse glycoconjugates in nature

BA Wagstaff, A Zorzoli, HC Dorfmueller - Biochemical Journal, 2021 - portlandpress.com
Rhamnose is an important 6-deoxy sugar present in many natural products, glycoproteins,
and structural polysaccharides. Whilst predominantly found as the l-enantiomer, instances of …