3′ UTR heterogeneity and cancer progression

JJ Chan, H Tabatabaeian, Y Tay - Trends in Cell Biology, 2023 - cell.com
The majority of human mRNAs generate alternative 3′ untranslated regions (UTRs)
through various processes, including RNA modifications such as RNA editing, m 6 A …

SNPs in 3′ UTR miRNA target sequences associated with individual drug susceptibility

E Rykova, N Ershov, I Damarov… - International Journal of …, 2022 - mdpi.com
The complementary interaction of microRNAs (miRNAs) with their binding sites in the 3′
untranslated regions (3′ UTRs) of target gene mRNAs represses translation, playing a …

Amplification-Free Strategy for miRNA Quantification in Human Serum Using Single Particle ICP–MS and Gold Nanoparticles as Labels

S González Morales, C López-Portugués… - Analytical …, 2024 - ACS Publications
MicroRNAs (miRNAs), which are short single-stranded RNA sequences between 18 and 24
nucleotides, are known to play a crucial role in gene expression. Changes in their …

[HTML][HTML] Consequences of genetic variants in miRNA genes

M Machowska, P Galka-Marciniak… - Computational and …, 2022 - Elsevier
MicroRNAs (miRNAs) are small non-coding RNAs that posttranscriptionally regulate the
expression of most genes. They are involved in regulating many physiological processes …

Structure-switchable hairpin-powered exponential replications for sensing attomolar microrna-related single nucleotide polymorphisms in human cancer tissues with …

L Wang, Q Han, J Hu, H Wang, M Liu… - Analytical …, 2022 - ACS Publications
MicroRNA (miRNA)-related single-nucleotide polymorphisms (miR-SNPs) are a novel class
of genetic variations involved in multiple cellular functions, and they have emerged as …

Methods for functional characterization of genetic polymorphisms of non-coding regulatory regions of the human genome

AN Uvarova, EA Tkachenko, EM Stasevich… - Biochemistry …, 2024 - Springer
Currently, numerous associations between genetic polymorphisms and various diseases
have been characterized through the Genome-Wide Association Studies. Majority of the …

Deciphering the role of KRAS gene in oncogenesis: Focus on signaling pathways, genetic alterations in 3'UTR, KRAS specific miRNAs and therapeutic interventions

Y Chhichholiya, HV Singh, R Vashistha, S Singh… - Critical reviews in …, 2024 - Elsevier
Cancer is a significant cause of death after cardiovascular disease. The genomic, epigenetic
and environmental factors have been found to be the risk factor for the disease. The most …

A bioinformatics toolbox to prioritize causal genetic variants in candidate regions

M Šimon, M Čater, T Kunej, NM Morton, S Horvat - Trends in Genetics, 2024 - cell.com
This review addresses the significant challenge of identifying causal genetic variants within
quantitative trait loci (QTLs) for complex traits and diseases. Despite progress in detecting …

Whole transcriptome sequencing analyses of islets reveal ncRNA regulatory networks underlying impaired insulin secretion and increased β-cell mass in high fat diet …

J Ma, R Gao, Q Xie, X Pan, N Tong - Plos one, 2024 - journals.plos.org
Aim Our study aims to identify novel non-coding RNA-mRNA regulatory networks associated
with β-cell dysfunction and compensatory responses in obesity-related diabetes. Methods …

miR-499a rs3746444 A> G Polymorphism Is Correlated with Type 2 Diabetes Mellitus and Diabetic Polyneuropathy in a Romanian Cohort: A Preliminary Study

E Burada, MM Roșu, RE Sandu, F Burada, MG Cucu… - Genes, 2023 - mdpi.com
Type 2 diabetes mellitus (T2DM) is a common metabolic disorder that results from complex
interactions of both environmental and genetic factors. Many single nucleotide …