Phage therapy in the postantibiotic era

FL Gordillo Altamirano, JJ Barr - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Antibiotic resistance is arguably the biggest current threat to global health. An increasing
number of infections are becoming harder or almost impossible to treat, carrying high …

Antibiotic discovery and resistance: the chase and the race

K Iskandar, J Murugaiyan, D Hammoudi Halat… - Antibiotics, 2022 - mdpi.com
The history of antimicrobial resistance (AMR) evolution and the diversity of the
environmental resistome indicate that AMR is an ancient natural phenomenon. Acquired …

World Health Organization report: current crisis of antibiotic resistance

A Talebi Bezmin Abadi, AA Rizvanov, T Haertlé… - BioNanoScience, 2019 - Springer
Antibiotic resistance is the most challenging clinical and public health problem. Despite of
living in the era of novel technologies in biomedical research, many of untreatable infectious …

New Treatment Options against Carbapenem-Resistant Acinetobacter baumannii Infections

B Isler, Y Doi, RA Bonomo… - Antimicrobial agents and …, 2019 - Am Soc Microbiol
Carbapenem-resistant Acinetobacter baumannii (CRAB) is a perilous nosocomial pathogen
causing substantial morbidity and mortality. Current treatment options for CRAB are limited …

Acinetobacter baumannii Resistance: A Real Challenge for Clinicians

R Vázquez-López, SG Solano-Gálvez… - Antibiotics, 2020 - mdpi.com
Acinetobacter baumannii (named in honor of the American bacteriologists Paul and Linda
Baumann) is a Gram-negative, multidrug-resistant (MDR) pathogen that causes nosocomial …

Bacteriophage therapy as an alternative treatment for human infections. A comprehensive review

A Kakasis, G Panitsa - International journal of antimicrobial agents, 2019 - Elsevier
Bacteriophages, or phages, are viruses that infect bacteria. They were discovered around a
century ago and have been used ever since for therapeutic purposes, particularly in former …

Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies of Acinetobacter baumannii

CO Vrancianu, I Gheorghe, IB Czobor, MC Chifiriuc - Microorganisms, 2020 - mdpi.com
Antibiotic resistance is one of the biggest challenges for the clinical sector and industry,
environment and societal development. One of the most important pathogens responsible …

Phage-antibiotic combination is a superior treatment against Acinetobacter baumannii in a preclinical study

FLG Altamirano, X Kostoulias, D Subedi, D Korneev… - …, 2022 - thelancet.com
Background Clinical phage therapy is often delivered alongside antibiotics. However, the
phenomenon of phage-antibiotic synergy has been mostly studied in vitro. Here, we …

Bacteriophages: protagonists of a post-antibiotic era

P Domingo-Calap, J Delgado-Martínez - Antibiotics, 2018 - mdpi.com
Despite their long success for more than half a century, antibiotics are currently under the
spotlight due to the emergence of multidrug-resistant bacteria. The development of new …

[HTML][HTML] Bacteriophage interactions with mammalian tissue: Therapeutic applications

H Huh, S Wong, JS Jean, R Slavcev - Advanced drug delivery reviews, 2019 - Elsevier
The human body is a large reservoir for bacterial viruses known as bacteriophages
(phages), which participate in dynamic interactions with their bacterial and human hosts that …