The pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily
includes nine hormones in humans that are related by structure, distribution (especially the …

The secretion of growth hormone (GH) is regulated through a complex neuroendocrine
control system, especially by the functional interplay of two hypothalamic hypophysiotropic …

I. Introduction T HE PERIOD of time spanning the interval between the first postulate of the
existence of a GH-releasing hormone (GRH) and the reports of its isolation and sequence …

Introduction G OLDMAN (1) in 1949 reported a patient with the combination of bronchial
endocrine tumor, pituitary adenoma composed of three cell types, and bilateral adrenal …

In the mammalian brain, a major regulatory peptide is vasoactive intestinal peptide (VIP).
This 28 amino acid peptide, originally isolated from the porcine duodenum, was later found …

The neurohumoral regulation of growth hormone secretion is mediated in part by two
hypothalamic peptides that reach the anterior pituitary via the hypothalamo-hypophysial …

Serum levels of GH and insulin-like growth factor I (IGF-I) were genetically increased to
investigate the physiological activities of these proteins. Lines of mice expressing chimeric …

Growth hormone (GH) is expressed specifically from the somatotroph cells of the anterior
pituitary, and GH transcription is under both cell type-specific and hormonal control (Figure …

The human gene encoding pituitary adenylate cyclase activating polypeptide (PACAP) was
isolated and its nucleotide sequence was determined. By comparison with a human PACAP …

Growth hormone-releasing hormone (GHRH) and pituitary adenylate cyclase-activating
polypeptide (PACAP) belong to the same superfamily of regulatory neuropeptides and have …