The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first
compartment of the secretory pathway. As such, the ER contributes to the production and …

Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

Transcription factors (TFs) regulate gene programs, thereby controlling diverse cellular
processes and cell states. To comprehensively understand TFs and the programs they …

Abstract The Cistrome Data Browser (DB) is a resource of human and mouse cis-regulatory
information derived from ChIP-seq, DNase-seq and ATAC-seq chromatin profiling assays …

Transcription factors (TFs) are major trans-acting factors in transcriptional regulation.
Therefore, elucidating TF–target interactions is a key step toward understanding the …

Summary cis-regulatory elements (CREs) encode the genomic blueprints of spatiotemporal
gene expression programs enabling highly specialized cell functions. Using single-cell …

INTRODUCTION Metazoan development represents a big jump in complexity compared
with unicellular life in two aspects: cell-type differentiation and cell spatial organization. In …

Abstract Hematopoietic Stem/Progenitor cells (HSPCs) are endowed with the role of
maintaining a diverse pool of blood cells throughout the human life. Despite recent efforts …

The use of mice as model organisms to study human biology is predicated on the genetic
and physiological similarities between the species. Nonetheless, mice and humans have …

The human CNS follows a pattern of development typical of all mammals, but certain
neurodevelopmental features are highly derived. Building the human CNS requires the …