Pivotal roles of GM‐CSF in autoimmunity and inflammation

A Shiomi, T Usui - Mediators of inflammation, 2015 - Wiley Online Library
Granulocyte macrophage‐colony stimulating factor (GM‐CSF) is a hematopoietic growth
factor, which stimulates the proliferation of granulocytes and macrophages from bone …

GM-CSF: a promising target in inflammation and autoimmunity

KMC Lee, AA Achuthan, JA Hamilton - ImmunoTargets and therapy, 2020 - Taylor & Francis
The cytokine, granulocyte macrophage-colony stimulating factor (GM-CSF), was firstly
identified as being able to induce in vitro the proliferation and differentiation of bone marrow …

Sodium chloride promotes pro-inflammatory macrophage polarization thereby aggravating CNS autoimmunity

S Hucke, M Eschborn, M Liebmann, M Herold… - Journal of …, 2016 - Elsevier
The increasing incidence in Multiple Sclerosis (MS) during the last decades in industrialized
countries might be linked to a change in dietary habits. Nowadays, enhanced salt content is …

A neuropeptide, Substance-P, directly induces tissue-repairing M2 like macrophages by activating the PI3K/Akt/mTOR pathway even in the presence of IFNγ

JE Lim, E Chung, Y Son - Scientific reports, 2017 - nature.com
Macrophage polarization plays an important role in tissue damage and repair. In this study,
we show that Substance-P (SP) can directly induce M2 polarization of inflammatory …

The pleiotropic effects of the GM-CSF rheostat on myeloid cell differentiation and function: more than a numbers game

Y Zhan, AM Lew, M Chopin - Frontiers in Immunology, 2019 - frontiersin.org
Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is a myelopoietic growth
factor that has pleiotropic effects not only in promoting the differentiation of immature …

AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages

Y Wang, B Viollet, R Terkeltaub… - Annals of the Rheumatic …, 2016 - ard.bmj.com
Objective AMP-activated protein kinase (AMPK) is metabolic biosensor with anti-
inflammatory activities. Gout is commonly associated with excesses in soluble urate and in …

[HTML][HTML] Isolation and culture of murine bone marrow-derived macrophages for nitric oxide and redox biology

JD Bailey, A Shaw, E McNeill, T Nicol, M Diotallevi… - Nitric Oxide, 2020 - Elsevier
Macrophages are mononuclear phagocytes derived from haematopoietic progenitors that
are widely distributed throughout the body. These cells participate in both innate and …

Interactions between type 1 interferons and the Th17 response in tuberculosis: lessons learned from autoimmune diseases

BC Mourik, E Lubberts, JEM De Steenwinkel… - Frontiers in …, 2017 - frontiersin.org
The classical paradigm of tuberculosis (TB) immunity, with a central protective role for Th1
responses and IFN-γ-stimulated cellular responses, has been challenged by unsatisfactory …

Mesenchymal stem cell paracrine activity is modulated by platelet lysate: induction of an inflammatory response and secretion of factors maintaining macrophages in a …

V Ulivi, R Tasso, R Cancedda… - Stem cells and …, 2014 - liebertpub.com
Wound healing is achieved through distinct programmed phases: hemostasis, inflammation,
mesenchymal cell proliferation and migration, and tissue remodeling. At the injury site, clot …

Type 3 secretion system induced leukotriene B4 synthesis by leukocytes is actively inhibited by Yersinia pestis to evade early immune recognition

A Brady, KR Sheneman, AR Pulsifer, SL Price… - Plos …, 2024 - journals.plos.org
Subverting the host immune response to inhibit inflammation is a key virulence strategy of
Yersinia pestis. The inflammatory cascade is tightly controlled via the sequential action of …