Chemical modifications of DNA have been recognized as key epigenetic mechanisms for
maintenance of the cellular state and memory. Such DNA modifications include canonical 5 …

Nanofluidic structures have over the last two decades emerged as a powerful platform for
detailed analysis of DNA on the kilobase pair length scale. When DNA is confined to a …

Next generation sequencing (NGS) is challenged by structural and copy number variations
larger than the typical read length of several hundred bases. Third-generation sequencing …

Optical DNA mapping has over the last decade emerged as a very powerful tool for
obtaining long range sequence information from single DNA molecules. In optical DNA …

The human genome contains multiple layers of information that extend beyond the genetic
sequence. In fact, identical genetics do not necessarily yield identical phenotypes as evident …

Detection of epigenetic markers, including 5-methylcytosine, is crucial due to their role in
gene expression regulation and due to the mounting evidence of aberrant DNA methylation …

Methyltransferases (MTases) form a large family of enzymes that methylate a diverse set of
targets, ranging from the three major biopolymers to small molecules. Most of these MTases …

Rapid characterization of unknown biological samples is under the focus of many current
studies. Here we report a method for screening of biological samples by optical mapping of …

A field of recent diagnostics and therapeutics has been advanced with quantum dots (QDs).
QDs have developed into new formats of biomolecular sensing to push the limits of detection …

Alzheimer disease (AD) is the primary form of dementia that occurs spontaneously in older
adults. Interestingly, the epigenetic profile of the cells forming the central nervous system …