The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation

J Haerinck, S Goossens, G Berx - Nature Reviews Genetics, 2023 - nature.com
Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

EMT transition states during tumor progression and metastasis

I Pastushenko, C Blanpain - Trends in cell biology, 2019 - cell.com
Epithelial–mesenchymal transition (EMT) is a process in which epithelial cells acquire
mesenchymal features. In cancer, EMT is associated with tumor initiation, invasion …

Distinct contributions of partial and full EMT to breast cancer malignancy

F Lüönd, N Sugiyama, R Bill, L Bornes, C Hager… - Developmental cell, 2021 - cell.com
Epithelial-mesenchymal transition (EMT) is a transient, reversible process of cell de-
differentiation where cancer cells transit between various stages of an EMT continuum …

Controversies around epithelial–mesenchymal plasticity in cancer metastasis

ED Williams, D Gao, A Redfern… - Nature Reviews Cancer, 2019 - nature.com
Experimental evidence accumulated over decades has implicated epithelial–mesenchymal
plasticity (EMP), which collectively encompasses epithelial–mesenchymal transition and the …

Identification of the tumour transition states occurring during EMT

I Pastushenko, A Brisebarre, A Sifrim, M Fioramonti… - Nature, 2018 - nature.com
In cancer, the epithelial-to-mesenchymal transition (EMT) is associated with tumour
stemness, metastasis and resistance to therapy. It has recently been proposed that, rather …

EMT factors and metabolic pathways in cancer

I Georgakopoulos-Soares, DV Chartoumpekis… - Frontiers in …, 2020 - frontiersin.org
The epithelial-mesenchymal transition (EMT) represents a biological program during which
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …

Systems biology of cancer metastasis

Y Suhail, MP Cain, K Vanaja, PA Kurywchak… - Cell systems, 2019 - cell.com
Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series
of concurrent, partially overlapping processes, as successfully metastasizing cells assume …

Cellular plasticity in cancer

S Yuan, RJ Norgard, BZ Stanger - Cancer discovery, 2019 - AACR
During cancer progression, tumor cells undergo molecular and phenotypic changes
collectively referred to as cellular plasticity. Such changes result from microenvironmental …

Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells

C Kröger, A Afeyan, J Mraz, EN Eaton… - Proceedings of the …, 2019 - National Acad Sciences
Carcinoma cells residing in an intermediate phenotypic state along the epithelial–
mesenchymal (E–M) spectrum are associated with malignant phenotypes, such as …

[HTML][HTML] Phenotypic plasticity: driver of cancer initiation, progression, and therapy resistance

PB Gupta, I Pastushenko, A Skibinski, C Blanpain… - Cell stem cell, 2019 - cell.com
Our traditional understanding of phenotypic plasticity in adult somatic cells comprises
dedifferentiation and transdifferentiation in the context of tissue regeneration or wound …