The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation
Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …
EMT transition states during tumor progression and metastasis
I Pastushenko, C Blanpain - Trends in cell biology, 2019 - cell.com
Epithelial–mesenchymal transition (EMT) is a process in which epithelial cells acquire
mesenchymal features. In cancer, EMT is associated with tumor initiation, invasion …
mesenchymal features. In cancer, EMT is associated with tumor initiation, invasion …
Distinct contributions of partial and full EMT to breast cancer malignancy
F Lüönd, N Sugiyama, R Bill, L Bornes, C Hager… - Developmental cell, 2021 - cell.com
Epithelial-mesenchymal transition (EMT) is a transient, reversible process of cell de-
differentiation where cancer cells transit between various stages of an EMT continuum …
differentiation where cancer cells transit between various stages of an EMT continuum …
Controversies around epithelial–mesenchymal plasticity in cancer metastasis
ED Williams, D Gao, A Redfern… - Nature Reviews Cancer, 2019 - nature.com
Experimental evidence accumulated over decades has implicated epithelial–mesenchymal
plasticity (EMP), which collectively encompasses epithelial–mesenchymal transition and the …
plasticity (EMP), which collectively encompasses epithelial–mesenchymal transition and the …
Identification of the tumour transition states occurring during EMT
In cancer, the epithelial-to-mesenchymal transition (EMT) is associated with tumour
stemness, metastasis and resistance to therapy. It has recently been proposed that, rather …
stemness, metastasis and resistance to therapy. It has recently been proposed that, rather …
EMT factors and metabolic pathways in cancer
I Georgakopoulos-Soares, DV Chartoumpekis… - Frontiers in …, 2020 - frontiersin.org
The epithelial-mesenchymal transition (EMT) represents a biological program during which
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …
Systems biology of cancer metastasis
Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series
of concurrent, partially overlapping processes, as successfully metastasizing cells assume …
of concurrent, partially overlapping processes, as successfully metastasizing cells assume …
Cellular plasticity in cancer
During cancer progression, tumor cells undergo molecular and phenotypic changes
collectively referred to as cellular plasticity. Such changes result from microenvironmental …
collectively referred to as cellular plasticity. Such changes result from microenvironmental …
Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells
Carcinoma cells residing in an intermediate phenotypic state along the epithelial–
mesenchymal (E–M) spectrum are associated with malignant phenotypes, such as …
mesenchymal (E–M) spectrum are associated with malignant phenotypes, such as …
[HTML][HTML] Phenotypic plasticity: driver of cancer initiation, progression, and therapy resistance
PB Gupta, I Pastushenko, A Skibinski, C Blanpain… - Cell stem cell, 2019 - cell.com
Our traditional understanding of phenotypic plasticity in adult somatic cells comprises
dedifferentiation and transdifferentiation in the context of tissue regeneration or wound …
dedifferentiation and transdifferentiation in the context of tissue regeneration or wound …