The interests in intestinal epithelial tuft cells, their basic physiology, involvement in immune
responses and relevance for gut diseases, have increased dramatically over the last fifteen …

Tuft cells are found in tissues with distinct stem cell compartments, tissue architecture, and
luminal exposures but converge on a shared transcriptional program, including expression …

A characteristic feature of host responses to helminth infections is the development of
profound systemic and tissue-localised Type 2 immune responses that play critical roles in …

Type 2 immune responses form a critical defence against enteric worm infections. In recent
years, mouse models have revealed shared and unique functions for group 2 innate …

The intestinal tract is a common site for various types of infections including viruses,
bacteria, and helminths, each requiring specific modes of immune defense. The intestinal …

Although tuft cells were discovered over 60 years ago, their functions have long been
enigmatic, especially in human health. Nonetheless, tuft cells have recently emerged as key …

Tuft cells are a rare and morphologically distinct chemosensory cell type found throughout
many organs, including the gastrointestinal tract. These cells were identified by their unique …

Epithelial cells in barrier tissues perform a critical immune function by detecting, restricting,
and often directly eliminating extrinsic pathogens. Membrane-bound and cytosolic pattern …

Pyroptosis is a lytic form of cell death that is executed by a family of pore-forming proteins
called gasdermins (GSDMs). GSDMs are activated upon proteolysis by host proteases …

The intestinal epithelium plays crucial roles in maintaining gut homeostasis. A key function
consists in constituting a physical and chemical barrier between self and non-self …