Ion mobility mass spectrometry (IM-MS) for structural biology: insights gained by measuring mass, charge, and collision cross section

E Christofi, P Barran - Chemical Reviews, 2023 - ACS Publications
The investigation of macromolecular biomolecules with ion mobility mass spectrometry (IM-
MS) techniques has provided substantial insights into the field of structural biology over the …

Physicochemical stability of monoclonal antibodies: a review

Y Le Basle, P Chennell, N Tokhadze, A Astier… - Journal of …, 2020 - Elsevier
Monoclonal antibodies (mAbs) are subject to instability issues linked to their protein nature.
In this work, we review the different mechanisms that can be linked to monoclonal antibodies …

Evaluation of peptide/protein self-assembly and aggregation by spectroscopic methods

MF Pignataro, MG Herrera, VI Dodero - Molecules, 2020 - mdpi.com
The self-assembly of proteins is an essential process for a variety of cellular functions
including cell respiration, mobility and division. On the other hand, protein or peptide …

Review of the current state of protein aggregation inhibition from a materials chemistry perspective: Special focus on polymeric materials

R Rajan, S Ahmed, N Sharma, N Kumar, A Debas… - Materials …, 2021 - pubs.rsc.org
Protein instability caused by exposure to external additives or severe stress may result in
different diseases. Of these diseases, many are triggered by protein misfolding and …

Mass spectrometry methods for measuring protein stability

DD Vallejo, C Rojas Ramírez, KF Parson, Y Han… - Chemical …, 2022 - ACS Publications
Mass spectrometry is a central technology in the life sciences, providing our most
comprehensive account of the molecular inventory of the cell. In parallel with developments …

Process analytical technologies and data analytics for the manufacture of monoclonal antibodies

MK Maruthamuthu, SR Rudge, AM Ardekani… - Trends in …, 2020 - cell.com
Process analytical technology (PAT) for the manufacture of monoclonal antibodies (mAbs) is
defined by an integrated set of advanced and automated methods that analyze the …

Phage-Displayed Nanobody as a Sensitive Nanoprobe to Enhance Chemiluminescent Immunoassay for Cronobacter sakazakii Detection in Dairy Products

Y Zhang, X Liao, G Yu, J Wei, P Wang… - Analytical …, 2023 - ACS Publications
The exploitation of stable, high-affinity, and low-cost nanoprobes is essential to develop
immunoassays for real-time monitoring of foodborne pathogens, so as to safeguard human …

nanoDSF as screening tool for enzyme libraries and biotechnology development

AO Magnusson, A Szekrenyi, HJ Joosten… - The FEBS …, 2019 - Wiley Online Library
Enzymes are attractive tools for synthetic applications. To be viable for industrial use,
enzymes need sufficient stability towards the desired reaction conditions such as high …

Ionic liquids and deep eutectic solvents for enhanced delivery of antibodies in the gastrointestinal tract

P Angsantikul, K Peng, AM Curreri… - Advanced Functional …, 2021 - Wiley Online Library
Monoclonal antibodies (mAbs) are currently used for the treatment of numerous conditions
including cancer, psoriasis, arthritis, and atopic dermatitis, among others. All mAbs are …

Synthesis and Application of CeO2/SnS2 Heterostructures as a Highly Efficient Coreaction Accelerator in the Luminol–Dissolved O2 System for Ultrasensitive …

L Yang, Y Jia, D Wu, Y Zhang, H Ju, Y Du… - Analytical …, 2019 - ACS Publications
Electrocheluminescence (ECL) immunoassay amplified by coreaction accelerators has
experienced major breakthroughs in ultrasensitive detection of biomarkers. Herein …