Human papillomaviruses (HPVs) are the etiologic agents of cervical and other epithelial
cancers. Persistence of infections by high-risk HPV types is the single greatest risk factor for …

Although the presentation of peptide–major histocompatibility complex class II (pMHC class
II) complexes to CD4 T cells has been studied extensively in vitro, knowledge of this process …

Innate and adaptive immune functions decline with age, leading to increased susceptibility
to infectious diseases and cancer, and reduced responses to preventive vaccination in the …

Acquisition of human papillomavirus (HPV) results in an infection of variable duration which
may or may not be associated with clinically apparent lesions. Lesions caused by skintropic …

Epidermal Langerhans cells (LCs) play a key role in immune defense mechanisms and in
numerous immunological disorders. In this report, we show that percutaneous infection of …

Interleukin-10 (IL-10) is a pleiotropic cytokine that modulates the function of several adaptive
immunity-related cells. Although generally considered an immunosuppressive molecule, IL …

This third edition is an update on every conceivable aspect of the modern-day management
of contact dermatitis. Both irritant and allergic contact dermatitis are covered clearly and …

Tumor necrosis factor-α (TNF-α) is well recognized for its role in mediating innate immune
responses. However, the mechanisms of TNF-α that influence the adaptive immune …

The role of CD4+ vs CD8+ T cells in contact hypersensitivity (CHS) remains controversial. In
this study, we used gene knockout (KO) mice deficient in CD4+ or CD8+ T cells to directly …

A common feature shared between several human cancer-associated viruses, such as
Epstein-Barr virus, Hepatitis B virus and Hepatitis C virus, and Human papillomavirus (HPV) …