Accurate genetic prediction of complex traits can facilitate disease screening, improve early
intervention, and aid in the development of personalized medicine. Genetic prediction of …

DNA methylation is an epigenetic modification that has consistently been shown to be linked
with a variety of human traits and diseases. Because DNA methylation is dynamic and …

We present and assess the UK Biobank (UKB) Polygenic Risk Score (PRS) Release, a set of
PRSs for 28 diseases and 25 quantitative traits being made available on the individuals in …

We assess the UK Biobank (UKB) Polygenic Risk Score (PRS) Release, a set of PRSs for 28
diseases and 25 quantitative traits that has been made available on the individuals in UKB …

Although the cohort-level accuracy of polygenic risk scores (PRSs)—estimates of genetic
value at the individual level—has been widely assessed, uncertainty in PRSs remains …

Cancer site–specific polygenic risk scores (PRS) effectively identify individuals at high risk of
individual cancers, but the effectiveness of PRS on overall cancer risk assessment and the …

The impact of genetic variation on overall disease burden has not been comprehensively
evaluated. We introduce an approach to estimate the effect of genetic risk factors on …

Aims To evaluate the independent, mediating, interactive, and associated effects of Life's
Essential 8 (LE8) and genetic predisposition on the risk of cardiovascular outcomes and all …

Prostate cancer (PrCa) is the second most common cancer worldwide in males. While
strongly warranted, the prediction of mortality risk due to PrCa, especially before its …

We construct a polygenic health index as a weighted sum of polygenic risk scores for 20
major disease conditions, including, eg, coronary artery disease, type 1 and 2 diabetes …