Continuous evaluation of drug safety is needed following approval to determine adverse
events (AEs) in patient populations with diverse backgrounds. Spontaneous reporting …

Antipsychotic drugs are commonly prescribed, mainly for the treatment of schizophrenia and
other psychotic disorders. Disproportionality analysis of pharmacovigilance data from …

Drug interactions between atorvastatin and cytochrome P450 (P450) 3A
substrates/inhibitors lead to an increased incidence of skeletal muscle or hepatic toxicity …

Among antipsychotics, clozapine is associated with a high risk of seizures. This study aimed
to generate novel hypotheses regarding trends in the onset of clozapine-induced seizures …

The impacts of polymorphic cytochrome P450 (P450 or CYP) 2C9 on drug interactions and
the pharmacokinetics of cyclooxygenase inhibitors have attracted considerable attention. In …

Background The quality of adverse drug reaction reports can have a strong influence on the
causality assessment or the detection of safety signals. Various methods have been used to …

Objectives: Intraocular administration of vascular endothelial growth factor (VEGF) inhibitors
may be associated with pregnancy loss. However, little is known about intraocular anti …

Cyclosporine is an immunosuppressant used to prevent organ rejection in kidney, liver, and
heart allogeneic transplants. This study aimed to assess the safety of cyclosporine through …

Aim We investigated adverse events (AEs) in a Japanese intensive care unit (ICU) and
evaluated the impact of cause‐specific AEs on mortality and length of stay. Design A …

The utility of big data in spontaneous adverse drug reactions (ADRs) reporting systems has
improved the pharmacovigilance process. However, identifying culprit drugs in ADRs …