Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …

Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …

Abstract The Nomenclature Committee of the International Society of Amyloidosis met at the
XVIII International Symposium on Amyloidosis in September and virtually in October 2022 …

Abstract The ISA Nomenclature Committee met electronically before and directly after the
XVII ISA International Symposium on Amyloidosis, which, unfortunately, had to be virtual in …

Frontotemporal lobar degeneration (FTLD) is the third most common neurodegenerative
condition after Alzheimer's and Parkinson's diseases. FTLD typically presents in 45 to 64 …

This review will focus on the process of amyloid-type protein aggregation. Amyloid fibrils are
an important hallmark of protein misfolding diseases and therefore have been investigated …

ATTR amyloidosis is caused by the deposition of transthyretin in the form of amyloid fibrils in
virtually every organ of the body, including the heart. This systemic deposition leads to a …

Despite much effort, antibody therapies for Alzheimer's disease (AD) have shown limited
efficacy. Challenges to the rational design of effective antibodies include the difficulty of …

Wild type transthyretin-derived amyloid (ATTRwt) is the major component of non-hereditary
transthyretin amyloidosis. Its accumulation in the heart of elderly patients is life threatening …

Amyotrophic lateral sclerosis and several other neurodegenerative diseases are associated
with brain deposits of amyloid-like aggregates formed by the C-terminal fragments of TDP …