Oxidative stress-mediated beta cell death and dysfunction as a target for diabetes management
S Dinić, J Arambašić Jovanović, A Uskoković… - Frontiers in …, 2022 - frontiersin.org
The biggest drawback of a current diabetes therapy is the treatment of the consequences not
the cause of the disease. Regardless of the diabetes type, preservation and recovery of …
the cause of the disease. Regardless of the diabetes type, preservation and recovery of …
Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice
X Hu, C Gattis, AG Olroyd, AM Friera, K White… - Science translational …, 2023 - science.org
Transplantation of allogeneic pancreatic donor islets has successfully been performed in
selected patients with difficult-to-control insulin-dependent diabetes and impaired …
selected patients with difficult-to-control insulin-dependent diabetes and impaired …
CRISPR–Cas9 delivery strategies for the modulation of immune and non-immune cells
CRISPR–Cas9 genome editing technology is a promising tool for genetically engineering
immune cells and modulating immune systems. Although ex vivo genome editing of immune …
immune cells and modulating immune systems. Although ex vivo genome editing of immune …
Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling
The glucagon-like peptide-1 receptor (GLP1R) is a class BG protein-coupled receptor
(GPCR) involved in glucose homeostasis and food intake. GLP1R agonists (GLP1RA) are …
(GPCR) involved in glucose homeostasis and food intake. GLP1R agonists (GLP1RA) are …
Single-cell transcriptome and accessible chromatin dynamics during endocrine pancreas development
E Duvall, CM Benitez, K Tellez… - Proceedings of the …, 2022 - National Acad Sciences
Delineating gene regulatory networks that orchestrate cell-type specification is a continuing
challenge for developmental biologists. Single-cell analyses offer opportunities to address …
challenge for developmental biologists. Single-cell analyses offer opportunities to address …
[HTML][HTML] β-cell neogenesis: A rising star to rescue diabetes mellitus
F Niu, W Liu, Y Ren, Y Tian, W Shi, M Li, Y Li… - Journal of advanced …, 2024 - Elsevier
Abstract Background Diabetes Mellitus (DM), a chronic metabolic disease characterized by
elevated blood glucose, is caused by various degrees of insulin resistance and …
elevated blood glucose, is caused by various degrees of insulin resistance and …
The multifaceted role of Fragile X-Related Protein 1 (FXR1) in cellular processes: an updated review on cancer and clinical applications
FA Khan, N Fang, W Zhang, S Ji - Cell Death & Disease, 2024 - nature.com
RNA-binding proteins (RBPs) modulate the expression level of several target RNAs (such as
mRNAs) post-transcriptionally through interactions with unique binding sites in the 3 …
mRNAs) post-transcriptionally through interactions with unique binding sites in the 3 …
Miniaturized surface engineered technologies for multiplex biosensing devices
The demand for quick, accurate, and affordable point‐of‐care (POC) devices increases with
the advancement in the dimensions of nanotechnology and digital interfaces (Internet of …
the advancement in the dimensions of nanotechnology and digital interfaces (Internet of …
Reagents and models for detecting endogenous GLP1R and GIPR
Abstract Glucagon-like peptide-1 receptor (GLP1R) agonists target the GLP1R, whereas
dual GLP1R/gastric inhibitory polypeptide receptor (GIPR) agonists target both the GLP1R …
dual GLP1R/gastric inhibitory polypeptide receptor (GIPR) agonists target both the GLP1R …
Drug delivery approaches for HuR-targeted therapy for lung cancer
Lung cancer (LC) is often diagnosed at an advanced stage and conventional treatments for
disease management have limitations associated with them. Novel therapeutic targets are …
disease management have limitations associated with them. Novel therapeutic targets are …