Protein Association in Solution: Statistical Mechanical Modeling
Protein molecules associate in solution, often in clusters beyond pairwise, leading to liquid
phase separations and high viscosities. It is often impractical to study these multi-protein …
phase separations and high viscosities. It is often impractical to study these multi-protein …
Melatonin: regulation of prion protein phase separation in cancer multidrug resistance
The unique ability to adapt and thrive in inhospitable, stressful tumor microenvironments
(TME) also renders cancer cells resistant to traditional chemotherapeutic treatments and/or …
(TME) also renders cancer cells resistant to traditional chemotherapeutic treatments and/or …
Critical beginnings: Selective tuning of solubility and structural accuracy of newly synthesized proteins by the Hsp70 chaperone system
RM Addabbo, RB Hutchinson, HJ Allaman… - The Journal of …, 2023 - ACS Publications
Proteins are particularly prone to aggregation immediately after release from the ribosome,
and it is therefore important to elucidate the role of chaperones during these key steps of …
and it is therefore important to elucidate the role of chaperones during these key steps of …
Fluorogenic methodology for visualization of phase separation in chemical biology
J Fang, Y Huang, J Wu, B Shen, Y Yang… - Organic & Biomolecular …, 2023 - pubs.rsc.org
Phase separation is a common biological phenomenon in the liquid environment of
organisms. Phase separation has been shown to be a key cause of many existing incurable …
organisms. Phase separation has been shown to be a key cause of many existing incurable …
The post-translational modification SUMO affects TDP-43 phase separation, compartmentalization, and aggregation in a zebrafish model
C Maurel, NM Scherer, A Hogan, A Vidal-Itriago… - bioRxiv, 2022 - biorxiv.org
SUMMARY TDP-43 is a nuclear RNA-binding protein that can undergo liquid-liquid phase
separation (LLPS) and forms pathological insoluble aggregates in frontotemporal dementia …
separation (LLPS) and forms pathological insoluble aggregates in frontotemporal dementia …
Characterizing the Self Association of the Intrinsically Disordered Low-Complexity Domain of the RNA Binding Protein EWS
CN Johnson - 2023 - search.proquest.com
The RNA-binding protein EWS is a multifunctional protein with roles in the regulation of
transcription and RNA splicing. It is one of the FET (FUS, EWS and TAF15) family of RNA …
transcription and RNA splicing. It is one of the FET (FUS, EWS and TAF15) family of RNA …