The regulation of antibody production is linked to the generation and maintenance of
plasmablasts and plasma cells from their B cell precursors. Plasmablasts are the rapidly …

Humoral immunity depends on the germinal centre (GC) reaction during which somatically
mutated high-affinity memory B cells and plasma cells are generated. Recent studies have …

Germinal centres (GCs) are involved in the selection of B cells secreting high-affinity
antibodies and are also the origin of most human B cell lymphomas. Recent progress has …

Memory B cells (MBCs) are critical for the rapid development of protective immunity
following re-infection. MBCs capable of neutralizing distinct subclasses of pathogens, such …

The superfamily of tripartite motif-containing (TRIM) proteins is conserved throughout the
metazoan kingdom and has expanded rapidly during vertebrate evolution; there are now …

The interferon regulatory factor (IRF) family, consisting of nine members in mammals, was
identified in the late 1980s in the context of research into the type I interferon system …

BCL6 is a transcriptional repressor required in mature B cells during the germinal center
(GC) reaction. Multiple mechanisms act coordinately to timely modulate BCL6 expression at …

We report the results of a meta-analysis of genome-wide association scans for multiple
sclerosis (MS) susceptibility that includes 2,624 subjects with MS and 7,220 control subjects …

Over the past several years, studies on normal and malignant B cells have provided new
insights into the unique physiology of the germinal centre (GC). In particular, advances in …

B cells producing high-affinity antibodies are destined to differentiate into memory B cells
and plasma cells, but the mechanisms leading to those differentiation pathways are mostly …