Neuronal wiring diagram of an adult brain

S Dorkenwald, A Matsliah, AR Sterling, P Schlegel… - Nature, 2024 - nature.com
Connections between neurons can be mapped by acquiring and analysing electron
microscopic brain images. In recent years, this approach has been applied to chunks of …

[HTML][HTML] Lessons from lonely flies: Molecular and neuronal mechanisms underlying social isolation

RSP Yadav, F Ansari, N Bera, C Kent… - … & Biobehavioral Reviews, 2024 - Elsevier
Animals respond to changes in the environment which affect their internal state by adapting
their behaviors. Social isolation is a form of passive environmental stressor that alters …

[HTML][HTML] Network statistics of the whole-brain connectome of Drosophila

A Lin, R Yang, S Dorkenwald, A Matsliah, AR Sterling… - Nature, 2024 - nature.com
Brains comprise complex networks of neurons and connections, similar to the nodes and
edges of artificial networks. Network analysis applied to the wiring diagrams of brains can …

The Neurotransmitters Involved in Drosophila Alcohol-Induced Behaviors

MM Chvilicek, I Titos, A Rothenfluh - Frontiers in behavioral …, 2020 - frontiersin.org
Alcohol is a widely used and abused substance with numerous negative consequences for
human health and safety. Historically, alcohol's widespread, non-specific neurobiological …

Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster

N Eckstein, AS Bates, A Champion, M Du, Y Yin… - Cell, 2024 - cell.com
High-resolution electron microscopy of nervous systems has enabled the reconstruction of
synaptic connectomes. However, we do not know the synaptic sign for each connection (ie …

Miniature neurotransmission is required to maintain Drosophila synaptic structures during ageing

S Banerjee, S Vernon, W Jiao, BJ Choi, E Ruchti… - Nature …, 2021 - nature.com
The decline of neuronal synapses is an established feature of ageing accompanied by the
diminishment of neuronal function, and in the motor system at least, a reduction of …

Widespread posttranscriptional regulation of cotransmission

N Chen, Y Zhang, EJ Rivera-Rodriguez, AD Yu… - Science …, 2023 - science.org
While neurotransmitter identity was once considered singular and immutable for mature
neurons, it is now appreciated that one neuron can release multiple neuroactive substances …

She's got nerve: roles of octopamine in insect female reproduction

MA White, DS Chen, MF Wolfner - Journal of neurogenetics, 2021 - Taylor & Francis
The biogenic monoamine octopamine (OA) is a crucial regulator of invertebrate physiology
and behavior. Since its discovery in the 1950s in octopus salivary glands, OA has been …

Botulinum neurotoxin accurately separates tonic vs. phasic transmission and reveals heterosynaptic plasticity rules in Drosophila

Y Han, C Chien, P Goel, K He, C Pinales, C Buser… - Elife, 2022 - elifesciences.org
In developing and mature nervous systems, diverse neuronal subtypes innervate common
targets to establish, maintain, and modify neural circuit function. A major challenge towards …

[HTML][HTML] Excess glutamate release triggers subunit-specific homeostatic receptor scaling

Y Han, P Goel, J Chen, S Perry, N Tran, S Nishimura… - Cell reports, 2023 - cell.com
Ionotropic glutamate receptors (GluRs) are targets for modulation in Hebbian and
homeostatic synaptic plasticity and are remodeled by development, experience, and …