Tuberculosis (TB) in humans is characterized by formation of immune-rich granulomas in
infected tissues, the architecture and composition of which are thought to affect disease …

The increasing use of high-throughput gene expression quantification technologies over the
last two decades and the fact that most of the published studies are stored in public …

There are fundamental differences between humans and the animals we typically use to
study the immune system. We have learned much from genetically manipulated and inbred …

It is often claimed that only experiments can support strong causal inferences and therefore
they should be privileged in the behavioral sciences. We disagree. Overvaluing experiments …

Background There is an urgent need for biomarkers to better stratify patients with idiopathic
pulmonary fibrosis by risk for lung transplantation allocation who have the same clinical …

Noninvasive blood tests that provide information about fetal development and gestational
age could potentially improve prenatal care. Ultrasound, the current gold standard, is not …

Improved risk stratification and prognosis prediction in sepsis is a critical unmet need.
Clinical severity scores and available assays such as blood lactate reflect global illness …

In silico quantification of cell proportions from mixed-cell transcriptomics data
(deconvolution) requires a reference expression matrix, called basis matrix. We hypothesize …

Gene Ontology (GO) enrichment analysis is ubiquitously used for interpreting high
throughput molecular data and generating hypotheses about underlying biological …

We found tremendous inequality across gene and protein annotation resources. We
observed that this bias leads biomedical researchers to focus on richly annotated genes …