The prevalence of diabetes mellitus (DM) is increasing worldwide, a consequence of the
alarming rise in obesity and metabolic syndrome (MetS). Oxidative stress and inflammation …

The endoplasmic reticulum (ER) stress response, also commonly known as the unfolded
protein response (UPR), is an adaptive response used to align ER functional capacity with …

Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic beta cells are killed by
infiltrating immune cells and by cytokines released by these cells. Signaling events …

Diabetic kidney disease (DKD) can occur in approximately 30–40% of both type 1 and type
2 diabetic patients. The well-established features of DKD include increased serum glucose …

Neonatal diabetes is caused by single gene mutations reducing pancreatic β cell number or
impairing β cell function. Understanding the genetic basis of rare diabetes subtypes …

Both common forms of diabetes have an inflammatory pathogenesis in which immune and
metabolic factors converge on interleukin-1β as a key mediator of insulin resistance and β …

A high caloric intake, rich in saturated fats, greatly contributes to the development of obesity,
which is the leading risk factor for type 2 diabetes (T2D). A persistent caloric surplus …

NLRP3 inflammasome is a multiprotein complex expressed in a variety of cells to stimulate
the production of inflammatory factors. Activation of NLRP3 inflammasome depends on a …

Diabetes is a metabolic disease affecting nearly 300 million individuals worldwide. Both
types of diabetes (1 and 2) are characterized by loss of functional pancreatic β-cell mass …

Abstract Type 1 diabetes (T1D) also known as juvenile diabetes is a chronic autoimmune
disorder that precipitates in genetically susceptible individuals by environmental factors …