Phosphodiesterase-4 (PDE4), mainly present in immune cells, epithelial cells, and brain
cells, manifests as an intracellular non-receptor enzyme that modulates inflammation and …

Cancer is a group of cells that malignantly grow and proliferate uncontrollably. At present,
treatment modes for cancer mainly comprise surgery, chemotherapy, radiotherapy …

The NF-κB transcription factor is the master regulator of the inflammatory response and is
essential for the homeostasis of the immune system. NF-κB regulates the transcription of …

NF-κB proteins are a family of transcription factors that are of central importance in
inflammation and immunity. NF-κB also plays important roles in other processes, including …

Members of the nuclear factor-κB (NF-κB) family of transcriptional regulators are central
mediators of the cellular inflammatory response. Although constitutive NF-κB signalling is …

Abstract Rationale: Breast cancer (BrCa) is the most common cancer worldwide, and the 5-
year relative survival rate has declined in patients diagnosed at stage IV. Advanced BrCa is …

The mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs by
relaying extracellular signals to intracellular responses. In mammals, there are more than a …

This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …

Nuclear factor-κB (NF-κB) consists of a family of transcription factors that play critical roles in
inflammation, immunity, cell proliferation, differentiation, and survival. Inducible NF-κB …

The transcription factor NF-κB has served as a standard for inducible transcription factors for
more than 20 years. The numerous stimuli that activate NF-κB, and the large number of …