mRNA has broad potential as a therapeutic. Current clinical efforts are focused on
vaccination, protein replacement therapies, and treatment of genetic diseases. The clinical …

Tuberculosis (TB) along with acquired immune deficiency syndrome and malaria rank
among the top three fatal infectious diseases which pose threat to global public health …

RNAs are involved in the crucial processes of disease progression and have emerged as
powerful therapeutic targets and diagnostic biomarkers. However, efficient delivery of …

Messenger RNA (mRNA) has immense potential for developing a wide range of therapies,
including immunotherapy and protein replacement. As mRNA presents no risk of integration …

Messenger RNA (mRNA) has become a promising class of drugs for diverse therapeutic
applications in the past few years. A series of clinical trials are ongoing or will be initiated in …

The field of gene therapy has evolved over the past two decades after the first introduction of
nucleic acid drugs, such as plasmid DNA (pDNA). With the development of in vitro …

Gene‐based therapy is one of essential therapeutic strategies for precision medicine
through targeting specific genes in specific cells of target tissues. However, there still exist …

Nano-based systems can be used to transport active medicinal products to specific parts of
the body. Most challenges with drug delivery, such as low water solubility and poor …

Nucleic acid-based therapies such as messenger RNA have the potential to revolutionize
modern medicine and enhance the performance of existing pharmaceuticals. The key …

Transcription, a critical process in molecular biology, has found many applications in RNA
synthesis, including mRNA vaccines and RNA therapeutics. However, current RNA …