[HTML][HTML] A guide to ERK dynamics, part 2: downstream decoding
A Ram, D Murphy, N DeCuzzi, M Patankar… - Biochemical …, 2023 - portlandpress.com
Signaling by the extracellular signal-regulated kinase (ERK) pathway controls many cellular
processes, including cell division, death, and differentiation. In this second installment of a …
processes, including cell division, death, and differentiation. In this second installment of a …
[HTML][HTML] PI3K signaling through a biochemical systems lens
Following 3 decades of extensive research into PI3K signaling, it is now evidently clear that
the underlying network does not equate to a simple ON/OFF switch. This is best illustrated by …
the underlying network does not equate to a simple ON/OFF switch. This is best illustrated by …
Information theory: new look at oncogenic signaling pathways
KA Zielińska, VL Katanaev - Trends in cell biology, 2019 - cell.com
Sustained pro-proliferative signaling is one of the hallmarks of cancer. Although it is
generally understood that the oncogenic signaling pathways are overactivated, or at least …
generally understood that the oncogenic signaling pathways are overactivated, or at least …
[HTML][HTML] Spatiotemporal clusters of ERK activity coordinate cytokine-induced inflammatory responses in human airway epithelial cells
NL DeCuzzi, DP Oberbauer, KJ Chmiel, M Pargett… - bioRxiv, 2024 - ncbi.nlm.nih.gov
OBJECTIVES:(1) To characterize spatiotemporal ERK activity in response to pro-
inflammatory ligands, and (2) to assess pharmacological and metabolic regulation of …
inflammatory ligands, and (2) to assess pharmacological and metabolic regulation of …
Mathematical modeling of the intracellular regulation of immune processes
DS Grebennikov, DO Donets, OG Orlova, J Argilaguet… - Molecular Biology, 2019 - Springer
The modern era of research in immunology is characterized by an unprecedented level of
detail about structural characteristics of the immune system and the regulation of activities of …
detail about structural characteristics of the immune system and the regulation of activities of …
Modeling Cellular Signaling Variability Based on Single-Cell Data: The TGF-SMAD Signaling Pathway
U Sarma, L Ripka, UA Anyaegbunam… - … Modeling of Signaling …, 2020 - Springer
Nongenetic heterogeneity is key to cellular decisions, as even genetically identical cells
respond in very different ways to the same external stimulus, eg, during cell differentiation or …
respond in very different ways to the same external stimulus, eg, during cell differentiation or …
Modeling Cellular Signaling Variability Based on Single-Cell Data: The TGFβ-SMAD Signaling Pathway
Nongenetic heterogeneity is key to cellular decisions, as even genetically identical cells
respond in very different ways to the same external stimulus, eg, during cell differentiation or …
respond in very different ways to the same external stimulus, eg, during cell differentiation or …