A global accounting of medically significant scorpions: Epidemiology, major toxins, and comparative resources in harmless counterparts

MJ Ward, SA Ellsworth, GS Nystrom - Toxicon, 2018 - Elsevier
Scorpions are an ancient and diverse venomous lineage, with over 2200 currently
recognized species. Only a small fraction of scorpion species are considered harmful to …

[HTML][HTML] Epidemiological review of scorpion envenomation in Iran

A Jalali, F Rahim - Iranian journal of pharmaceutical research …, 2014 - ncbi.nlm.nih.gov
This epidemiological review was carried out to display the magnitude and the geographic
distribution of scorpion envenomation in Iran with focus on the southwestern region of Iran …

A review of epidemiological, clinical and in vitro physiological studies of envenomation by the scorpion Hemiscorpius lepturus (Hemiscorpiidae) in Iran

A Jalali, MH Pipelzadeh, R Sayedian, EG Rowan - Toxicon, 2010 - Elsevier
Many of the published accounts of envenomation by Hemiscorpius lepturus (H. lepturus) are
in a form that makes it difficult for non Farsi readers to access. The purpose of this review is …

Scorpion Toxins Specific for Potassium (K+) Channels: A Historical Overview of Peptide Bioengineering

ZL Bergeron, JP Bingham - Toxins, 2012 - mdpi.com
Scorpion toxins have been central to the investigation and understanding of the
physiological role of potassium (K+) channels and their expansive function in membrane …

Scorpion venom (Odontobuthus doriae) induces apoptosis by depolarization of mitochondria and reduces S-phase population in human breast cancer cells (MCF-7)

J Zargan, S Umar, M Sajad, M Naime, S Ali, HA Khan - Toxicology in vitro, 2011 - Elsevier
Venom of some species of scorpions induces apoptosis and arrests proliferation in cancer
cells. This is an important property that can be harnessed and can lead to isolation of …

Scorpion toxin peptide action at the ion channel subunit level

DM Housley, GD Housley, MJ Liddell, EA Jennings - Neuropharmacology, 2017 - Elsevier
This review categorizes functionally validated actions of defined scorpion toxin (SCTX)
neuropeptides across ion channel subclasses, highlighting key trends in this rapidly …

Molecular diversity and functional evolution of scorpion potassium channel toxins

S Zhu, S Peigneur, B Gao, L Luo, D Jin, Y Zhao… - Molecular & Cellular …, 2011 - ASBMB
Scorpion toxins affecting K+ channels (KTxs) represent important pharmacological tools and
potential drug candidates. Here, we report molecular characterization of seven new KTxs in …

KV1. 2 channel-specific blocker from Mesobuthus eupeus scorpion venom: Structural basis of selectivity

AI Kuzmenkov, OV Nekrasova, S Peigneur… - …, 2018 - Elsevier
Scorpion venom is an unmatched source of selective high-affinity ligands of potassium
channels. There is a high demand for such compounds to identify and manipulate the …

Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels

CH Thompson, PR Olivetti, MD Fuller… - Journal of biological …, 2009 - ASBMB
The ClC protein family includes voltage-gated chloride channels and chloride/proton
exchangers. In eukaryotes, ClC proteins regulate membrane potential of excitable cells …

Mass spectrometric analysis of Odonthobuthus Doriae scorpion venom and its non-neutralized fractions after interaction with commercial antivenom

A Abdollahnia, K Bahmani, A Aliahmadi, MA As' habi… - Scientific Reports, 2024 - nature.com
It is believed that antivenoms play a crucial role in neutralizing venoms. However,
uncontrolled clinical effects appear in patients stung by scorpions after the injection of …