Long non-coding RNAs (lncRNAs) are a diverse class of RNAs that engage in numerous
biological processes across every branch of life. Although initially discovered as mRNA-like …

During protein synthesis, ribosomes encounter many roadblocks, the outcomes of which are
largely determined by substrate availability, amino acid features and reaction kinetics …

Transcription termination occurs when the polymerase is released after a transcription event,
thus delimitating transcription units; however, the functional importance of termination …

Although most mRNA molecules derived from protein-coding genes are destined to be
translated into functional polypeptides, some are eliminated by cellular quality control …

Most DNA in the genomes of higher organisms does not encode proteins, yet much is
transcribed by RNA polymerase II (RNAPII) into long non-coding RNAs (lncRNAs). The …

Eukaryotic genomes are pervasively transcribed. However, it is unclear how many newly
found RNAs have functions and how many are byproducts of functional, or spurious …

Pervasive transcription of eukaryotic genomes stems to a large extent from bidirectional
promoters that synthesize mRNA and divergent noncoding RNA (ncRNA). Here, we show …

The cycle of eukaryotic transcription, from initiation to elongation and termination is
regulated at multiple steps. Coordinated action of regulatory factors keeps in check the …

The Set3 histone deacetylase complex (Set3C) binds histone H3 dimethylated at lysine 4
(H3K4me2) to mediate deacetylation of histones in 5′-transcribed regions. To discern how …

Termination of transcription by RNA polymerase II requires two distinct processes: The
formation of a defined 3′ end of the transcribed RNA, as well as the disengagement of RNA …