Dendritic cells (DCs) can be viewed as translators between innate and adaptive immunity.
They integrate signals derived from tissue infection or damage and present processed …

The spleen is the largest secondary lymphoid organ in the body and, as such, hosts a wide
range of immunologic functions alongside its roles in hematopoiesis and red blood cell …

BACKGROUND Sphingosine 1-phosphate (S1P), a product of membrane sphingolipid
metabolism, is secreted and acts through G protein–coupled S1P receptors (S1PRs) in …

B cells play a central role in the immunopathogenesis of glomerulonephritides and
transplant rejection. B cells secrete antibodies that contribute to tissue injury via multiple …

In recent years, various intervention strategies have reduced malaria morbidity and mortality,
but further improvements probably depend upon development of a broadly protective …

Sphingolipids are ubiquitous building blocks of eukaryotic cell membranes. Progress in our
understanding of sphingolipid metabolism, state-of-the-art sphingolipidomic approaches …

The ability to align individual cellular information from multiple experimental sources is
fundamental for a systems-level understanding of biological processes. However, currently …

The spleen is the main filter for blood-borne pathogens and antigens, as well as a key organ
for iron metabolism and erythrocyte homeostasis. Also, immune and hematopoietic functions …

During the last two decades, an increasing number of reports have pointed out that the
immunogenicity of polyethylene glycol (PEG) may trigger accelerated blood clearance …

Membrane sphingolipids are metabolized to sphingosine-1-phosphate (S1P), a bioactive
lipid mediator that regulates many processes in vertebrate development, physiology, and …