Riluzole and edaravone: A tale of two amyotrophic lateral sclerosis drugs
MK Jaiswal - Medicinal Research Reviews, 2019 - Wiley Online Library
Over the past decades, a multitude of experimental drugs have been shown to delay
disease progression in preclinical animal models of amyotrophic lateral sclerosis (ALS) but …
disease progression in preclinical animal models of amyotrophic lateral sclerosis (ALS) but …
On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK
The reactions of N 1‐acetyl‐N 2‐formyl‐5‐methoxykynuramine (AFMK) and N 1‐acetyl‐5‐
methoxykynuramine (AMK) with• OH,• OOH, and• OOCC l3 radicals have been studied using …
methoxykynuramine (AMK) with• OH,• OOH, and• OOCC l3 radicals have been studied using …
Melatonin as a natural ally against oxidative stress: a physicochemical examination
Oxidative stress has been proven to be related to the onset of a large number of health
disorders. This chemical stress is triggered by an excess of free radicals, which are …
disorders. This chemical stress is triggered by an excess of free radicals, which are …
Targeting oxidative stress in central nervous system disorders
M Patel - Trends in pharmacological sciences, 2016 - cell.com
There is widespread recognition that reactive oxygen species (ROS) play key roles in
normal brain function and pathology in the context of neurological disease. Oxidative stress …
normal brain function and pathology in the context of neurological disease. Oxidative stress …
Computational strategies for predicting free radical scavengers' protection against oxidative stress: where are we and what might follow?
A Galano, J Raúl Alvarez‐Idaboy - International Journal of …, 2019 - Wiley Online Library
Oxidative stress, which is frequently induced by an overproduction of free radicals (FR),
poses a high risk to human health. Thus, finding efficient strategies for scavenging FR is a …
poses a high risk to human health. Thus, finding efficient strategies for scavenging FR is a …
How is edaravone effective against acute ischemic stroke and amyotrophic lateral sclerosis?
K Watanabe, M Tanaka, S Yuki, M Hirai… - Journal of clinical …, 2018 - jstage.jst.go.jp
抄録 Edaravone is a low-molecular-weight antioxidant drug targeting peroxyl radicals
among many types of reactive oxygen species. Because of its amphiphilicity, it scavenges …
among many types of reactive oxygen species. Because of its amphiphilicity, it scavenges …
A computational methodology for accurate predictions of rate constants in solution: Application to the assessment of primary antioxidant activity
A Galano, JR Alvarez‐Idaboy - Journal of computational …, 2013 - Wiley Online Library
The accurate prediction of rate constants for chemical reactions in solution, using
computational methods, is a challenging task. In this work, a computational protocol …
computational methods, is a challenging task. In this work, a computational protocol …
Theoretical and experimental studies of the antioxidant and antinitrosant activity of syringic acid
Syringic acid (SA) is a natural phenolic acid found in vegetables, fruits, and other plant-
based foods. A range of biological activities were proposed for this compound including …
based foods. A range of biological activities were proposed for this compound including …
Antioxidant Activity of trans-Resveratrol toward Hydroxyl and Hydroperoxyl Radicals: A Quantum Chemical and Computational Kinetics Study
In this work, we have carried out a systematic study of the antioxidant activity of trans-
resveratrol toward hydroxyl (• OH) and hydroperoxyl (• OOH) radicals in aqueous simulated …
resveratrol toward hydroxyl (• OH) and hydroperoxyl (• OOH) radicals in aqueous simulated …
A physicochemical examination of the free radical scavenging activity of Trolox: mechanism, kinetics and influence of the environment
The free radical scavenging activity of Trolox was studied for aqueous and lipid
environments using the Density Functional Theory. Several reaction mechanisms and free …
environments using the Density Functional Theory. Several reaction mechanisms and free …