Adult Leydig cells (ALCs) are the steroidogenic cells in the testes that produce testosterone.
ALCs develop postnatally from a pool of stem cells, referred to as stem Leydig cells (SLCs) …

BACKGROUND Leydig cells (LC) are the sites of testicular androgen production.
Development of LC occurs in the testes of most mammalian species as two distinct growth …

Leydig cells (LCs) are thought to differentiate from spindle-shaped precursor cells that
exhibit some aspects of differentiated function, including 3β-hydroxysteroid dehydrogenase …

The ability to identify and isolate lineage-specific stem cells from adult tissues could facilitate
cell replacement therapy. Leydig cells (LCs) are the primary source of androgen in the …

Ghrelin, the endogenous ligand for the GH secretagogue receptor (GHS-R), has been
primarily linked to the central neuroendocrine regulation of GH secretion and food intake …

Sex steroids are crucial regulators of sexual differentiation and the proper development of
secondary sex characteristics and patterns of sexual behavior. Since Leydig cells are the …

Testicular Leydig cells are the primary source of testosterone in males. Adult Leydig cells
have been shown to arise from stem cells present in the neonatal testis. Once established …

Bisphenol A (BPA) is a ubiquitous environmental pollutant, mainly from the manufacture and
use of plastics. The use of BPA is restricted, and its new analogs (including bisphenol AF …

It is generally agreed that estrogens, principally estradiol-17β, are synthesized by and act in
the testis of mammals, including humans. The site of estradiol synthesis in the testis is …

This review centers around studies which have used ethane dimethane sulphonate (EDS)
selectively to destroy all of the Leydig cells in the adult rat testis. With additional …