Targeting apoptosis in cancer therapy

BA Carneiro, WS El-Deiry - Nature reviews Clinical oncology, 2020 - nature.com
For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

[HTML][HTML] Understanding apoptosis and apoptotic pathways targeted cancer therapeutics

R Jan - Advanced pharmaceutical bulletin, 2019 - ncbi.nlm.nih.gov
Various physiological processes involve appropriate tissue developmental process and
homeostasis-the pathogenesis of several diseases connected with deregulatory apoptosis …

[HTML][HTML] Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies

G Pistritto, D Trisciuoglio, C Ceci, A Garufi… - Aging (albany …, 2016 - ncbi.nlm.nih.gov
Apoptosis is a form of programmed cell death that results in the orderly and efficient removal
of damaged cells, such as those resulting from DNA damage or during development …

[HTML][HTML] Capsaicin: current understanding of its mechanisms and therapy of pain and other pre-clinical and clinical uses

V Fattori, MSN Hohmann, AC Rossaneis… - Molecules, 2016 - mdpi.com
In this review, we discuss the importance of capsaicin to the current understanding of
neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We …

Targeting cancer cells with nanotherapeutics and nanodiagnostics: Current status and future perspectives

ES Ali, SM Sharker, MT Islam, IN Khan, S Shaw… - Seminars in cancer …, 2021 - Elsevier
Nanotechnology is reshaping health care strategies and is expected to exert a tremendous
impact in the coming years offering better healthcare facilities. It has led to not only …

Ethanolic Extract of Lagerstroemia Speciosa (L.) Pers., Induces Apoptosis and Cell Cycle Arrest in HepG2 Cells

T Rohit Singh, D Ezhilarasan - Nutrition and cancer, 2020 - Taylor & Francis
Abstract Lagerstroemia speciosa (L.) Pers.,(Lythraceae) also called Banaba is a native plant
of southeast Asia and is widely used in traditional medicinal system. Herbal tea from banaba …

[HTML][HTML] Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative breast cancer cells

N Pizato, BC Luzete, LFMV Kiffer, LH Corrêa… - Scientific reports, 2018 - nature.com
The implication of inflammation in pathophysiology of several type of cancers has been
under intense investigation. Omega-3 fatty acids can modulate inflammation and present …

Caspase-8: The double-edged sword

R Mandal, JC Barrón, I Kostova, S Becker… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Caspase-8 is a cysteine-aspartate specific protease that classically triggers the extrinsic
apoptotic pathway, in response to the activation of cell surface Death Receptors (DRs) like …

[HTML][HTML] Peptide-based agents for cancer treatment: current applications and future directions

NTT Nhàn, T Yamada, KH Yamada - International Journal of Molecular …, 2023 - mdpi.com
Peptide-based strategies have received an enormous amount of attention because of their
specificity and applicability. Their specificity and tumor-targeting ability are applied to …

[HTML][HTML] Thymoquinone (2-Isopropyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects

A Ahmad, RK Mishra, A Vyawahare, A Kumar… - Saudi Pharmaceutical …, 2019 - Elsevier
Cancer remains the topmost disorder of the mankind and number of cases is unceasingly
growing at unprecedented rates. Although the synthetic anti-cancer compounds still hold the …