The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

Oridonin, as a natural terpenoids found in traditional Chinese herbal medicine Isodon
rubescens (Hemsl.) H. Hara, is widely present in numerous Chinese medicine preparations …

We are witnessing the globalization of a specific type of arteriosclerosis with rising
prevalence, incidence and an overall cardiovascular disease burden. Currently …

In recent years, due to their distinctive and adaptable therapeutic effects, many natural
bioactive compounds have been commonly used to treat diseases. Their limited solubility …

Disordered immune regulation and persistent inflammatory damage are the key
mechanisms of ventilator-induced lung injury (VILI). NLR family pyrin domain containing 3 …

The role of circular RNA (circRNA) in radiation‐induced liver disease (RILD) remains largely
unknown. In this study, Ras‐related C3 botulinum toxin substrate 1 (RAC1) was elevated in …

Liver fibrosis is characterized by the activation of hepatic stellate cells (HSCs) and
accumulation of the extracellular matrix. There are limitations in the current therapies for liver …

Aim: Acute-on-chronic liver failure (ACLF) is closely related to mitochondrial dysfunction.
Previous studies showed the vital role of mitofusin2 (Mfn2) in the regulation of mitochondrial …

Non-alcoholic fatty liver disease (NAFLD) is a chronic inflammatory disease characterized
by “multiple crosstalk” paths of insulin resistance, lipid metabolism, oxidative stress, etc. The …

Oridonin, the major terpene isolated from Rabdosia rubescens, has been used as dietary
supplement. Recently, it has been known to exhibit anti-inflammatory effect. This study we …