Classical cadherins are the key molecules that control cell–cell adhesion. Notwithstanding
this function, it is also clear that classical cadherins are more than just the “glue” that keeps …

Epigenetic modifications represent mechanisms by which cells may effectively translate
multiple signaling inputs into phenotypic outputs. Recent research is revealing that redox …

We performed exome sequencing to detect somatic mutations in protein-coding regions in
seven melanoma cell lines and donor-matched germline cells. All melanoma samples had …

Type 1 diabetes mellitus (T1DM) is a disease where destruction of the insulin producing
pancreatic beta-cells leads to increased blood sugar levels. Both genetic and environmental …

Adherens junctions, which are intercellular adhesive complexes that are crucial for
maintaining epithelial homeostasis, are downregulated in many cancers to promote tumour …

The canonical Wnt signalling pathway plays a key role during embryogenesis and defects in
this pathway have been implicated in the pathogenesis of various types of tumours …

Breast cancer is the most common cause of cancer death among women under age 50
years, so it is imperative to identify molecular markers to improve diagnosis and prognosis of …

The epigenetic silencing of tumor suppressor genes is a common event during
carcinogenesis, and often involves aberrant DNA methylation and histone modification of …

Normal mammary morphogenesis involves transitions between simple and multilayered
epithelial organizations. We used electron microscopy and molecular markers to determine …

Much evidence now attests to the importance of desmosomes and their constituents in
cancer. Alterations in the expression of desmosomal components could contribute to the …