We have reviewed the literature and have identified more than 100 diseases or conditions
that are associated with raised concentrations of plasma total homocysteine. The …

Cobalamin is an essential molecule for humans. It acts as a cofactor in one-carbon transfers
through methylation and molecular rearrangement. These functions take place in fatty acid …

Every 5 years, the JAS publishes guidelines for the treatment of dyslipidemia and
atherosclerosis. To date, this society has released four such guidelines. Since 2007, the JAS …

Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse …

Abstract Concepts of atherogenesis have evolved considerably with time. Early animal
experiments showed that a cholesterol-rich diet could induce fatty lesion formation in …

Reduced glomerular filtration rate defines chronic kidney disease and is associated with
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …

Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via
poorly understood mechanisms. We performed a trans-ancestry genome-wide association …

Objective To determine which potentially modifiable risk factors, including socioeconomic,
lifestyle/dietary, cardiometabolic, and inflammatory factors, are associated with Alzheimer's …

Background Whether a modestly elevated homocysteine level is causally associated with an
increased risk of cardiovascular disease remains unestablished. We conducted a Mendelian …

The liking and selective ingestion of palatable foods—including sweets—is biologically
controlled, and dysfunction of this regulation may promote unhealthy eating, obesity, and …