Abstract Overactive phosphoinositide 3-kinase (PI3K) in cancer and immune dysregulation
has spurred extensive efforts to develop therapeutic PI3K inhibitors. Although progress has …

Obesity is a disorder with an increasing prevalence, which impairs the life quality of patients
and intensifies societal health care costs. The development of safe and innovative …

Obesity and type 2 diabetes mellitus are complicated metabolic diseases that affect multiple
organs and are characterized by hyperglycaemia. Currently, stable and effective treatments …

The mechanism of insulin action is a central theme in biology and medicine. In addition to
the rather rare condition of insulin deficiency caused by autoimmune destruction of …

Several metabolic alterations accumulate over time along with a reduction in biological
fitness, suggesting the existence of a" metabolic clock" that controls aging. Multiple inborn …

Abstract Phosphoinositide 3-kinase (PI3K) signaling regulates cellular proliferation, survival
and metabolism, and its aberrant activation is one of the most frequent oncogenic events …

PIK3CA is one of the most commonly mutated genes in solid cancers. PIK3CA mutations are
also found in benign overgrowth syndromes, collectively known as PIK3CA-related …

The prevalence of obesity, of type 2 diabetes mellitus (T2DM), and of cancer are all
increasing globally. The relationships between these diseases are complex, and thus …

Abstract Purpose of Review This perspective is motivated by the need to question dogma
that does not work: that the problem is insulin resistance (IR). We highlight the need to …

Overnutrition causes obesity, a global health problem without any effective therapy. Obesity
is characterized by low-grade inflammation, which predisposes individuals to metabolic …