Radiotherapy-induced digestive injury: diagnosis, treatment and mechanisms

G Chen, Y Han, H Zhang, W Tu, S Zhang - Frontiers in oncology, 2021 - frontiersin.org
Radiotherapy is one of the main therapeutic methods for treating cancer. The digestive
system consists of the gastrointestinal tract and the accessory organs of digestion (the …

Voxel-based analysis in radiation oncology: A methodological cookbook

G Palma, S Monti, L Cella - Physica Medica, 2020 - Elsevier
Recently, 2D or 3D methods for dose distribution analysis have been proposed as
evolutions of the Dose Volume Histogram (DVH) approaches. Those methods, collectively …

Spatial descriptions of radiotherapy dose: normal tissue complication models and statistical associations

MA Ebert, S Gulliford, O Acosta… - Physics in Medicine …, 2021 - iopscience.iop.org
For decades, dose-volume information for segmented anatomy has provided the essential
data for correlating radiotherapy dosimetry with treatment-induced complications. Dose …

Dose/volume histogram patterns in salivary gland subvolumes influence xerostomia injury and recovery

P Han, P Lakshminarayanan, W Jiang, I Shpitser… - Scientific reports, 2019 - nature.com
Xerostomia is a common consequence of radiotherapy in head and neck cancer. The
objective was to compare the regional radiation dose distribution in patients that developed …

[HTML][HTML] Associations between voxel-level accumulated dose and rectal toxicity in prostate radiotherapy

LEA Shelley, MPF Sutcliffe, SJ Thomas… - Physics and Imaging in …, 2020 - Elsevier
Abstract Background and Purpose Associations between dose and rectal toxicity in prostate
radiotherapy are generally poorly understood. Evaluating spatial dose distributions to the …

PACE: a probabilistic atlas for normal tissue complication estimation in radiation oncology

G Palma, S Monti, A Buonanno, R Pacelli… - Frontiers in …, 2019 - frontiersin.org
In radiation oncology, the need for a modern Normal Tissue Complication Probability
(NTCP) philosophy to include voxel-based evidence on organ radio-sensitivity (RS) has …

Patterns in ano-rectal dose maps and the risk of late toxicity after prostate IMRT

E Onjukka, C Fiorino, A Cicchetti, F Palorini… - Acta …, 2019 - Taylor & Francis
Purpose: The aim of this work was to determine how the spatial pattern of dose in the ano-
rectal wall is related to late gastro-intestinal toxicity for prostate cancer patients treated with …

Experimental validation of a novel method of dose accumulation for the rectum

HM Patrick, E Poon, J Kildea - Acta Oncologica, 2023 - Taylor & Francis
Abstract Background Dose-surface maps (DSMs) are an increasingly popular tool to
evaluate spatial dose-outcome relationships for the rectum. Recently, DSM addition has …

Local dose effects for late gastrointestinal toxicity after hypofractionated and conventionally fractionated modern radiotherapy for prostate cancer in the HYPRO trial

WD Heemsbergen, L Incrocci, FJ Pos… - Frontiers in …, 2020 - frontiersin.org
Purpose: Late gastrointestinal (GI) toxicity after radiotherapy for prostate cancer may have
significant impact on the cancer survivor's quality of life. To date, little is known about local …

[HTML][HTML] Application of an automated dose accumulation workflow in high-risk prostate cancer-validation and dose-volume analysis between planned and delivered …

A Ong, K Knight, V Panettieri, M Dimmock, JKL Tuan… - Medical …, 2022 - Elsevier
Inter-fraction organ variations cause deviations between planned and delivered doses in
patients receiving radiotherapy for prostate cancer. This study compared planned (DP) vs …