Targeted protein degradation (TPD) has been established as a viable alternative to
attenuate the function of a specific protein of interest in both biological and clinical contexts …

Oligonucleotide-based therapeutics have attracted attention as an emerging modality that
includes the modulation of genes and their binding proteins related to diseases, allowing us …

The conception, synthesis, and invention of a nanostructure, now known as the spherical
nucleic acid, or SNA, in 1996 marked the advent of a new field of chemistry. Over the past …

Bispecific chimeras bridging cell membrane proteins with lysosome‐trafficking receptors
(LTRs) provide an effective therapeutic approach through lysosomal degradation of disease …

A foundational principle of rational vaccinology is that vaccine structure plays a critical role
in determining therapeutic efficacy, but in order to establish fundamental, effective, and …

The selective transport of molecular cargo is critical in many biological and
chemical/materials processes and applications. Although nature has evolved highly efficient …

Cancer immunotherapy is a powerful treatment strategy that mobilizes the immune system to
fight disease. Cancer vaccination is one form of cancer immunotherapy, where …

Site-specific chemical conjugation has long been a challenging endeavor in the field of
ligand-directed modification to produce homogeneous conjugates for precision medicine …

Subunit vaccines based on antigen proteins or epitopes of pathogens or tumors show
advantages in immunological precision and high safety, but are often limited by their low …

The working efficiency of traditional 3D DNA nanomachines is extremely restricted due to
the complex DNA components modified on nanoparticles in the same spatial height. Herein …