The role of Toll-like receptors and neuroinflammation in Parkinson's disease
Background Parkinson's disease (PD) is the second most prevalent neurodegenerative
disorder, characterized by motor and non-motor symptoms, significantly affecting patients' …
disorder, characterized by motor and non-motor symptoms, significantly affecting patients' …
Pathophysiology and therapeutic perspectives of oxidative stress and neurodegenerative diseases: a narrative review
Introduction Neurodegeneration is the term describing the death of neurons both in the
central nervous system and periphery. When affecting the central nervous system, it is …
central nervous system and periphery. When affecting the central nervous system, it is …
Parkinson's disease, aging and adult neurogenesis: Wnt/β‐catenin signalling as the key to unlock the mystery of endogenous brain repair
B Marchetti, C Tirolo, F L'Episcopo, S Caniglia… - Aging cell, 2020 - Wiley Online Library
A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …
Mouse primary microglia respond differently to LPS and poly (I: C) in vitro
Y He, N Taylor, X Yao, A Bhattacharya - Scientific Reports, 2021 - nature.com
Microglia, CNS resident innate immune cells, respond strongly to activation of TLR3 and
TLR4, which recognize viral dsRNA poly (I: C) and bacterial endotoxin LPS, respectively …
TLR4, which recognize viral dsRNA poly (I: C) and bacterial endotoxin LPS, respectively …
Targeting nuclear receptors in neurodegeneration and neuroinflammation
S Willems, D Zaienne, D Merk - Journal of medicinal chemistry, 2021 - ACS Publications
Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …
expression upon ligand signals and present as attractive therapeutic targets especially in …
Protective microglia and their regulation in Parkinson's disease
W Le, J Wu, Y Tang - Frontiers in Molecular Neuroscience, 2016 - frontiersin.org
Microglia-mediated neuroinflammation is a hallmark of Parkinson's disease (PD). In the
brains of patients with PD, microglia have both neurotoxic and neuroprotective effects …
brains of patients with PD, microglia have both neurotoxic and neuroprotective effects …
Molecular insights into NR4A2 (Nurr1): an emerging target for neuroprotective therapy against neuroinflammation and neuronal cell death
NR4A2 is a nuclear receptor and a transcription factor, with distinctive physiological
features. In the cell nuclei of the central nervous system, it is widely expressed and identified …
features. In the cell nuclei of the central nervous system, it is widely expressed and identified …
Nurr1‐based therapies for Parkinson's disease
Previous studies have documented that orphan nuclear receptor Nurr1 (also known as NR
4A2) plays important roles in the midbrain dopamine (DA) neuron development …
4A2) plays important roles in the midbrain dopamine (DA) neuron development …
Medicinal chemistry and chemical biology of Nurr1 modulators: an emerging strategy in neurodegeneration
S Willems, D Merk - Journal of Medicinal Chemistry, 2022 - ACS Publications
Nuclear receptor related 1 (Nurr1) is a transcription factor with neuroprotective and
antineuroinflammatory properties. Observations from genetic studies and human patients …
antineuroinflammatory properties. Observations from genetic studies and human patients …
Recruitment of the CoREST transcription repressor complexes by Nerve Growth factor IB-like receptor (Nurr1/NR4A2) mediates silencing of HIV in microglial cells
Human immune deficiency virus (HIV) infection in the brain leads to chronic
neuroinflammation due to the production of pro-inflammatory cytokines, which in turn …
neuroinflammation due to the production of pro-inflammatory cytokines, which in turn …