Physics and biomedical challenges of cancer therapy with accelerated heavy ions

M Durante, J Debus, JS Loeffler - Nature Reviews Physics, 2021 - nature.com
Radiotherapy should have low toxicity in the entrance channel (normal tissue) and be very
effective in cell killing in the target region (tumour). In this regard, ions heavier than protons …

Transforming nuclear medicine with nanoradiopharmaceuticals

I Roy, S Krishnan, AV Kabashin, IN Zavestovskaya… - ACS …, 2022 - ACS Publications
Nuclear medicine is expected to make major advances in cancer diagnosis and therapy;
tumor-targeted radiopharmaceuticals preferentially eradicate tumors while causing minimal …

Technological advancements in external beam radiation therapy (EBRT): An indispensable tool for cancer treatment

K Koka, A Verma, BS Dwarakanath… - Cancer Management …, 2022 - Taylor & Francis
Recent technological advancements have increased the efficacy of radiotherapy, leading to
effective management of cancer patients with enhanced patient survival and improved …

Simultaneous dose and dose rate optimization (SDDRO) of the FLASH effect for pencil‐beam‐scanning proton therapy

H Gao, J Liu, Y Lin, GN Gan, G Pratx, F Wang… - Medical …, 2022 - Wiley Online Library
Abstract Purpose Compared to CONV‐RT (with conventional dose rate), FLASH‐RT (with
ultra‐high dose rate) can provide biological dose sparing for organs‐at‐risk (OARs) via the …

Ultra‐high dose rate radiation production and delivery systems intended for FLASH

J Farr, V Grilj, V Malka, S Sudharsan… - Medical …, 2022 - Wiley Online Library
Higher dose rates, a trend for radiotherapy machines, can be beneficial in shortening
treatment times for radiosurgery and mitigating the effects of motion. Recently, even higher …

Developing an accurate model of spot-scanning treatment delivery time and sequence for a compact superconducting synchrocyclotron proton therapy system

L Zhao, G Liu, S Chen, J Shen, W Zheng, A Qin… - Radiation …, 2022 - Springer
Background A new compact superconducting synchrocyclotron single-room proton solution
delivers pulsed proton beams to each spot through several irradiation bursts calculated by …

Radioactive beams in particle therapy: past, present, and future

M Durante, K Parodi - Frontiers in physics, 2020 - frontiersin.org
Heavy ion therapy can deliver high doses with high precision. However, image guidance is
needed to reduce range uncertainty. Radioactive ions are potentially ideal projectiles for …

Clinical commissioning of intensity‐modulated proton therapy systems: report of AAPM Task Group 185

JB Farr, MF Moyers, CE Allgower, M Bues… - Medical …, 2021 - Wiley Online Library
Proton therapy is an expanding radiotherapy modality in the United States and worldwide.
With the number of proton therapy centers treating patients increasing, so does the need for …

Particle therapy in the future of precision therapy

L Schaub, SB Harrabi, J Debus - The British journal of radiology, 2020 - academic.oup.com
The first hospital-based treatment facilities for particle therapy started operation about thirty
years ago. Since then, the clinical experience with protons and carbon ions has grown …

Future developments in charged particle therapy: improving beam delivery for efficiency and efficacy

J Yap, A De Franco, S Sheehy - Frontiers in Oncology, 2021 - frontiersin.org
The physical and clinical benefits of charged particle therapy (CPT) are well recognized.
However, the availability of CPT and complete exploitation of dosimetric advantages are still …