Role of gene regulation and inter species interaction as a key factor in gut microbiota adaptation
Gut microbiota is a class of microbial flora present in various eukaryotic multicellular
complex animals such as human beings. Their community's growth and survival are greatly …
complex animals such as human beings. Their community's growth and survival are greatly …
A modified fluctuation assay reveals a natural mutator phenotype that drives mutation spectrum variation within Saccharomyces cerevisiae
Although studies of Saccharomyces cerevisiae have provided many insights into
mutagenesis and DNA repair, most of this work has focused on a few laboratory strains …
mutagenesis and DNA repair, most of this work has focused on a few laboratory strains …
Population genomics reveals evolution and variation of Saccharomyces cerevisiae in the human and insects gut
The quest to discover the variety of ecological niches inhabited by Saccharomyces
cerevisiae has led to research in areas as diverse as wineries, oak trees and insect guts …
cerevisiae has led to research in areas as diverse as wineries, oak trees and insect guts …
Deep sequencing of natural and experimental populations of Drosophila melanogaster reveals biases in the spectrum of new mutations
Mutations provide the raw material of evolution, and thus our ability to study evolution
depends fundamentally on having precise measurements of mutational rates and patterns …
depends fundamentally on having precise measurements of mutational rates and patterns …
A generalizable deep learning framework for inferring fine-scale germline mutation rate maps
Y Fang, S Deng, C Li - Nature Machine Intelligence, 2022 - nature.com
Germline mutation rates are essential for genetic and evolutionary analyses. Yet, estimating
accurate fine-scale mutation rates across the genome is a great challenge, due to relatively …
accurate fine-scale mutation rates across the genome is a great challenge, due to relatively …
Cytosine methylation affects the mutability of neighboring nucleotides in germline and soma
V Kusmartsev, M Drożdż, B Schuster-Böckler… - Genetics, 2020 - academic.oup.com
Methylated cytosines deaminate at higher rates than unmethylated cytosines, and the
lesions they produce are repaired less efficiently. As a result, methylated cytosines are …
lesions they produce are repaired less efficiently. As a result, methylated cytosines are …
Intrinsic base substitution patterns in diverse species reveal links to cancer and metabolism
SP Gelova, KN Doherty, S Alasmar, K Chan - Genetics, 2022 - academic.oup.com
Analyses of large-scale cancer sequencing data have revealed that mutagenic processes
can create distinctive patterns of base substitutions, called mutational signatures …
can create distinctive patterns of base substitutions, called mutational signatures …
Massively parallel experimental interrogation of natural variants in ancient signaling pathways reveals both purifying selection and local adaptation
The nature of standing genetic variation remains a central debate in population genetics,
with differing perspectives on whether common variants are mostly neutral or have …
with differing perspectives on whether common variants are mostly neutral or have …
Evolutionary Constraints in Saccharomyces Vineyard Adaptation
ER Longan - 2024 - search.proquest.com
Evolutionary constraints are a broad topic that encompass any factor that may limit the
evolution of a population. These constraints are important because they determine whether …
evolution of a population. These constraints are important because they determine whether …
Natural selection
N Saitou, N Saitou - Introduction to Evolutionary Genomics, 2018 - Springer
Basic concept of natural selection is first discussed, and purifying or negative selection is
shown to be much more prevalent than positive selection. Various types of natural selections …
shown to be much more prevalent than positive selection. Various types of natural selections …