Non-tuberculous mycobacterial pulmonary disease
S Cowman, J van Ingen, DE Griffith… - European Respiratory …, 2019 - Eur Respiratory Soc
Nontuberculous mycobacterial pulmonary disease (NTM-PD) is a challenging infection
which is becoming increasingly prevalent, particularly in the elderly, for reasons which are …
which is becoming increasingly prevalent, particularly in the elderly, for reasons which are …
Structural and functional diversity of resistance–nodulation–cell division transporters
Multidrug resistant (MDR) bacteria are a global threat with many common infections
becoming increasingly difficult to eliminate. While significant effort has gone into the …
becoming increasingly difficult to eliminate. While significant effort has gone into the …
MmpL Proteins in Physiology and Pathogenesis of M. tuberculosis
G Melly, GE Purdy - Microorganisms, 2019 - mdpi.com
Mycobacterium tuberculosis (Mtb) remains an important human pathogen. The Mtb cell
envelope is a critical bacterial structure that contributes to virulence and pathogenicity …
envelope is a critical bacterial structure that contributes to virulence and pathogenicity …
Transporters involved in the biogenesis and functionalization of the mycobacterial cell envelope
The biology of mycobacteria is dominated by a complex cell envelope of unique composition
and structure and of exceptionally low permeability. This cell envelope is the basis of many …
and structure and of exceptionally low permeability. This cell envelope is the basis of many …
Direct inhibition of MmpL3 by novel antitubercular compounds
MmpL3, an essential transporter involved in the export of mycolic acids, is the proposed
target of a number of antimycobacterial inhibitors under development. Whether MmpL3 …
target of a number of antimycobacterial inhibitors under development. Whether MmpL3 …
Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target
Tuberculosis (TB) is the leading cause of death from a single infectious agent and in 2019
an estimated 10 million people worldwide contracted the disease. Although treatments for …
an estimated 10 million people worldwide contracted the disease. Although treatments for …
Extreme Drug Tolerance of Mycobacterium abscessus “Persisters”
Persistence of infection despite extensive chemotherapy with antibiotics displaying low MICs
is a hallmark of lung disease caused by Mycobacterium abscessus (Mab). Thus, the …
is a hallmark of lung disease caused by Mycobacterium abscessus (Mab). Thus, the …
Pipeline of anti‐Mycobacterium abscessus small molecules: Repurposable drugs and promising novel chemical entities
The Mycobacterium abscessus complex is a group of emerging pathogens that are difficult
to treat. There are no effective drugs for successful M. abscessus pulmonary infection …
to treat. There are no effective drugs for successful M. abscessus pulmonary infection …
Active Benzimidazole Derivatives Targeting the MmpL3 Transporter in Mycobacterium abscessus
C Raynaud, W Daher, MD Johansen… - ACS infectious …, 2019 - ACS Publications
The prevalence of pulmonary infections due to nontuberculous mycobacteria such as
Mycobacterium abscessus has been increasing and surpassing tuberculosis (TB) in some …
Mycobacterium abscessus has been increasing and surpassing tuberculosis (TB) in some …
Proton transfer activity of the reconstituted Mycobacterium tuberculosis MmpL3 is modulated by substrate mimics and inhibitors
CM Stevens, SO Babii, AN Pandya… - Proceedings of the …, 2022 - National Acad Sciences
Transporters belonging to the Resistance-Nodulation-cell Division (RND) superfamily of
proteins such as Mycobacterium tuberculosis MmpL3 and its analogs are the focus of …
proteins such as Mycobacterium tuberculosis MmpL3 and its analogs are the focus of …