In broad terms, there are 3 types of cardiac hypertrophy: normal growth, growth induced by
physical conditioning (ie, physiologic hypertrophy), and growth induced by pathologic …

Proteins of the interleukin-6 (IL-6) family bind to receptors in the plasma membrane.
Subsequent signal transduction involves activation of the janus kinase (JAK) and signal …

LEOPARD syndrome (LS) is an autosomal dominant “RASopathy” that manifests with
congenital heart disease. Nearly all cases of LS are caused by catalytically inactivating …

Rationale: The heart can be protected from infarction by brief episodes of
ischemia/reperfusion of a remote organ. Remote ischemic preconditioning (RIPC) by brief …

Objective Remote ischemic preconditioning protects the myocardium from
ischemia/reperfusion injury. We recently identified protection by remote ischemic …

Cardiovascular diseases cause more mortality and morbidity worldwide than any other
diseases. Although many intracellular signaling pathways influence cardiac physiology and …

In response to a variety of extrinsic and intrinsic stimuli that impose increased biomechanical
stress the heart responds by enlarging the individual myofibers. Even though myocardial …

The signal transducer and activator of transcription 3 (STAT3) is fundamental for
physiological homeostasis and stress-induced remodelling of the heart as deregulated …

Current therapy of pulmonary arterial hypertension (PAH) is inadequate.
Dehydroepiandrosterone (DHEA) effectively treats experimental pulmonary hypertension in …

Cytokines are important mediators of cardiac disease. Accumulating evidence indicates that
members of the interleukin-6 family of cytokines promote cardiac hypertrophy through the …