The plasticity of mRNA translation during cancer progression and therapy resistance

L Fabbri, A Chakraborty, C Robert, S Vagner - Nature Reviews Cancer, 2021 - nature.com
Translational control of mRNAs during gene expression allows cells to promptly and
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …

Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them

K Leppek, R Das, M Barna - Nature reviews Molecular cell biology, 2018 - nature.com
RNA molecules can fold into intricate shapes that can provide an additional layer of control
of gene expression beyond that of their sequence. In this Review, we discuss the current …

Ribosome biogenesis in cancer: new players and therapeutic avenues

J Pelletier, G Thomas, S Volarević - Nature Reviews Cancer, 2018 - nature.com
The ribosome is a complex molecular machine composed of numerous distinct proteins and
nucleic acids and is responsible for protein synthesis in every living cell. Ribosome …

The discovery of ribosome heterogeneity and its implications for gene regulation and organismal life

NR Genuth, M Barna - Molecular cell, 2018 - cell.com
The ribosome has recently transitioned from being viewed as a passive, indiscriminate
machine to a more dynamic macromolecular complex with specialized roles in the cell …

Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis

RY Ebright, S Lee, BS Wittner, KL Niederhoffer… - Science, 2020 - science.org
Circulating tumor cells (CTCs) are shed into the bloodstream from primary tumors, but only a
small subset of these cells generates metastases. We conducted an in vivo genome-wide …

Ribosomopathies: There's strength in numbers

EW Mills, R Green - Science, 2017 - science.org
BACKGROUND Ribosomopathies are a heterogeneous group of human disorders that are
in some cases known, and in other cases suspected, to result from ribosome dysfunction …

Ribosome levels selectively regulate translation and lineage commitment in human hematopoiesis

RK Khajuria, M Munschauer, JC Ulirsch, C Fiorini… - Cell, 2018 - cell.com
Blood cell formation is classically thought to occur through a hierarchical differentiation
process, although recent studies have shown that lineage commitment may occur earlier in …

Non-AUG translation: a new start for protein synthesis in eukaryotes

MG Kearse, JE Wilusz - Genes & development, 2017 - genesdev.cshlp.org
Although it was long thought that eukaryotic translation almost always initiates at an AUG
start codon, recent advancements in ribosome footprint mapping have revealed that non …

A synaptic perspective of fragile X syndrome and autism spectrum disorders

C Bagni, RS Zukin - Neuron, 2019 - cell.com
Altered synaptic structure and function is a major hallmark of fragile X syndrome (FXS),
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are …

Ribosome profiling: global views of translation

NT Ingolia, JA Hussmann… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
The translation of messenger RNA (mRNA) into protein and the folding of the resulting
protein into an active form are prerequisites for virtually every cellular process and represent …