Functions of BLM helicase in cells: is it acting like a double-edged sword?
DNA damage repair response is an important biological process involved in maintaining the
fidelity of the genome in eukaryotes and prokaryotes. Several proteins that play a key role in …
fidelity of the genome in eukaryotes and prokaryotes. Several proteins that play a key role in …
BARD1 mystery: tumor suppressors are cancer susceptibility genes
The full-length BRCA1-associated RING domain 1 (BARD1) gene encodes a 777-aa
protein. BARD1 displays a dual role in cancer development and progression as it acts as a …
protein. BARD1 displays a dual role in cancer development and progression as it acts as a …
Genetic data sharing and artificial intelligence in the era of personalized medicine based on a cross‐sectional analysis of the Saudi human genome program
The success of the Saudi Human Genome Program (SHGP), one of the top ten genomic
programs worldwide, is highly dependent on the Saudi population embracing the concept of …
programs worldwide, is highly dependent on the Saudi population embracing the concept of …
A network-based analysis reveals the mechanism underlying vitamin D in suppressing cytokine storm and virus in SARS-CoV-2 infection
F Ahmed - Frontiers in immunology, 2020 - frontiersin.org
Background SARS-CoV-2 causes ongoing pandemic coronavirus disease of 2019 (COVID-
19), infects the cells of the lower respiratory tract that leads to a cytokine storm in a …
19), infects the cells of the lower respiratory tract that leads to a cytokine storm in a …
In silico investigations identified Butyl Xanalterate to competently target CK2α (CSNK2A1) for therapy of chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is an incurable malignancy of B-cells. In this study,
bioinformatics analyses were conducted to identify possible pathogenic roles of CK2α …
bioinformatics analyses were conducted to identify possible pathogenic roles of CK2α …
Influence of PRKCE non-synonymous variants on protein dynamics and functionality
Novel protein kinase C (nPKC) family member, protein kinase C epsilon (PKCε) is an AGC
kinase superfamily member. It is associated with neurological and metabolic diseases as …
kinase superfamily member. It is associated with neurological and metabolic diseases as …
[Retracted] In Silico Identification of Hub Genes as Observing Biomarkers for Gastric Cancer Metastasis
A Ajucarmelprecilla, J Pandi… - Evidence‐Based …, 2022 - Wiley Online Library
Perception of hub genes engaged in metastatic gastric cancer (mGC) promotes novel ways
to diagnose and treat the illness. The goal of this investigation is to recognize the hub genes …
to diagnose and treat the illness. The goal of this investigation is to recognize the hub genes …
Identification and characterization of novel mutations in chronic kidney disease (CKD) and autosomal dominant polycystic kidney disease (ADPKD) in Saudi subjects …
Background: Autosomal dominant polycystic kidney disease (ADPKD) is a condition usually
caused by a single gene mutation and manifested by both renal and extrarenal features …
caused by a single gene mutation and manifested by both renal and extrarenal features …
A Comprehensive Analysis of cis-Acting RNA Elements in the SARS-CoV-2 Genome by a Bioinformatics Approach
The emergence of a new coronavirus (CoV), severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2), responsible for severe respiratory disease in humans termed coronavirus …
2 (SARS-CoV-2), responsible for severe respiratory disease in humans termed coronavirus …
The BLM helicase is a new therapeutic target in multiple myeloma involved in replication stress survival and drug resistance
S Ovejero, E Viziteu, L Dutrieux, J Devin… - Frontiers in …, 2022 - frontiersin.org
Multiple myeloma (MM) is a hematologic cancer characterized by accumulation of malignant
plasma cells in the bone marrow. To date, no definitive cure exists for MM and resistance to …
plasma cells in the bone marrow. To date, no definitive cure exists for MM and resistance to …