Vascular endothelial cells play an important role in the regulation of vascular function in
response to mechanical stimuli in both healthy and diseased states. Prostaglandin I2 (PGI2) …

This study aimed to clarify the role of glypican-1 and PECAM-1 in shear-induced nitric oxide
production in endothelial cells. Atomic force microscopy pulling was used to apply force to …

Duchenne muscular dystrophy (DMD) is a life-threatening neuromuscular disease caused
by the lack of dystrophin, resulting in progressive muscle wasting and locomotor …

We studied by conventional and speckle-tracking echocardiography, the response of the left
ventricle (LV) to a three-week continuous infusion of isoproterenol (Iso), a non-specific beta …

AMP-activated protein kinase (AMPK) is a key regulator of energy homeostasis under
conditions of energy stress. Though heart is one of the most energy requiring organs and …

While classical cannabinoid receptors are known to crucially impact on myocardial infarction
(MI) repair, a function of the cannabinoid-sensitive receptor GPR55 herein is poorly …

We aimed to determine the pathophysiological impact of heart rate (HR) slowing on cardiac
function. We have recently developed a murine model in which it is possible to conditionally …

Although autosomal dominant polycystic kidney disease (ADPKD) is characterized by the
development of multiple kidney cysts, the most frequent cause of death in ADPKD patients is …

Aims B56α is a protein phosphatase 2A (PP2A) regulatory subunit that is highly expressed
in the heart. We previously reported that cardiomyocyte B56α localizes to myofilaments …

Aims: In cardiac myocytes, the sarcomeric Z-disc protein telethonin is constitutively bis-
phosphorylated at C-terminal residues S157 and S161; however, the functional significance …