The molecular virology of coronaviruses
E Hartenian, D Nandakumar, A Lari, M Ly… - Journal of Biological …, 2020 - ASBMB
Few human pathogens have been the focus of as much concentrated worldwide attention as
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its …
Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein
J Lei, Y Kusov, R Hilgenfeld - Antiviral research, 2018 - Elsevier
The multi-domain non-structural protein 3 (Nsp3) is the largest protein encoded by the
coronavirus (CoV) genome, with an average molecular mass of about 200 kD. Nsp3 is an …
coronavirus (CoV) genome, with an average molecular mass of about 200 kD. Nsp3 is an …
The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein
The multifunctional nucleocapsid (N) protein in SARS-CoV-2 binds the~ 30 kb viral RNA
genome to aid its packaging into the 80–90 nm membrane-enveloped virion. The N protein …
genome to aid its packaging into the 80–90 nm membrane-enveloped virion. The N protein …
[HTML][HTML] Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites
S Kang, M Yang, Z Hong, L Zhang, Z Huang… - … Pharmaceutica Sinica B, 2020 - Elsevier
The outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 virus continually
lead to worldwide human infections and deaths. Currently, there is no specific viral protein …
lead to worldwide human infections and deaths. Currently, there is no specific viral protein …
[HTML][HTML] The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
Abstract The SARS-CoV-2 nucleocapsid (N) protein is an abundant RNA-binding protein
critical for viral genome packaging, yet the molecular details that underlie this process are …
critical for viral genome packaging, yet the molecular details that underlie this process are …
Phosphoregulation of phase separation by the SARS-CoV-2 N protein suggests a biophysical basis for its dual functions
The nucleocapsid (N) protein of coronaviruses serves two major functions: compaction of the
RNA genome in the virion and regulation of viral gene transcription. It is not clear how the N …
RNA genome in the virion and regulation of viral gene transcription. It is not clear how the N …
Genomic RNA elements drive phase separation of the SARS-CoV-2 nucleocapsid
C Iserman, CA Roden, MA Boerneke, RSG Sealfon… - Molecular cell, 2020 - cell.com
We report that the SARS-CoV-2 nucleocapsid protein (N-protein) undergoes liquid-liquid
phase separation (LLPS) with viral RNA. N-protein condenses with specific RNA genomic …
phase separation (LLPS) with viral RNA. N-protein condenses with specific RNA genomic …
SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs
Tightly packed complexes of nucleocapsid protein and genomic RNA form the core of
viruses and assemble within viral factories, dynamic compartments formed within the host …
viruses and assemble within viral factories, dynamic compartments formed within the host …
Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the coronavirus disease 2019 (COVID-19). SARS-CoV-2 is a single-stranded positive-sense …
the coronavirus disease 2019 (COVID-19). SARS-CoV-2 is a single-stranded positive-sense …
Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy
The current pandemic situation caused by the Betacoronavirus SARS-CoV-2 (SCoV2)
highlights the need for coordinated research to combat COVID-19. A particularly important …
highlights the need for coordinated research to combat COVID-19. A particularly important …