Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …

The barrier function of host cells enables intracellular bacteria to evade the lethality of the
host immune system and antibiotics, thereby causing chronic and recurrent infections that …

Glycosylation of eukaryotic virus particles is common and influences their uptake, trafficking,
and immune recognition. In contrast, glycosylation of bacteriophage particles has not been …

Intracellular human pathogens are the deadliest infectious diseases and pose great difficulty
to effectively treat due to their protection inside the host cell and the development of …

The discovery of molecules that could shorten the treatment period of tuberculosis (TB)
holds the promise of improving the current regimen. Polyamines are organic polycationic …

The global threat posed by antimicrobial resistance demands urgent action and the
development of effective drugs. Lower respiratory tract infections remain the deadliest …

ATP provides energy in the biosynthesis of cellular metabolites as well as regulates protein
functions through phosphorylation. Many ATP-dependent enzymes are antibacterial and …

Background It was previously shown that GlnA3sc enabled Streptomyces coelicolor to
survive in excess polyamines. However, subsequent studies revealed that Rv1878, the …

Compounds targeting host control of infectious diseases provide an attractive alternative to
antimicrobials. A phenotypic screen of a kinase library identified compounds targeting …

Tuberculosis is the leading bacterial killer worldwide. 8-Nitro-4H-benzo [e][1, 3] thiazin-4-
ones are a potent class of antitubercular agents with a new mechanism of action. BTZ043 …