Alteration in the density and composition of extracellular matrix (ECM) occurs in tumors. The
alterations toward both stiffness and degradation are contributed to tumor growth and …

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease that typically features a
dramatic desmoplastic reaction, especially fibroblasts. The roles of cancer-associated …

The metastasis is a multistep process in which a small proportion of cancer cells are
detached from the colony to enter into blood cells for obtaining a new place for metastasis …

Pancreatic ductal adenocarcinoma (PDAC) constitutes one of the most challenging lethal
tumors and has a very poor prognosis. In addition to cancer cells, the tumor …

Metastasis is a complicated, multistep process that is responsible for over 90% of cancer-
related death. Metastatic disease or the movement of cancer cells from one site to another …

Cancer development and progression are closely associated with changes both in the
mechano-cellular phenotype of cancer and stromal cells and in the extracellular matrix …

Background: Tumorigenesis is attributed to the interactions of cancer cells with the tumor
microenvironment through both biochemical cues and physical stimuli. Increased matrix …

Mechanical cues in the cell microenvironment such as those from extracellular matrix
properties, stretching, compression and shear stress, play a critical role in maintaining …

Pancreatic cancer is the 4th leading cause of cancer deaths in the United States. The
pancreatic cancer phenotype is primarily a consequence of oncogenes disturbing the …

The extracellular matrix (ECM) is a significant factor in cancer progression. Collagens, as the
main component of the ECM, are greatly remodeled alongside cancer development. More …